viernes, 27 de noviembre de 2009

BAD FAITH AND LIES .DR GERONIMO RODRIGUEZ LAST MISLEADING SUMMARY.SERIOUS INCOINGRUENCES WITH DEATH CERTIFICATE AND HOSPITAL´S ATTESTATION



PAYING ATTENTION OVER RODRIGUEZ DISCHARGE SUMMARY YOU CAN REALIZE THAT HE NEVER SAY EVEN A WORD ABOUT THE DIAGNOSIS.OF COURSE THAT TELLING THE TRUE DIAGNOSIS WHICH HAS BEEN INFORMED TO HIM AFTER VERO´S STROKE,HE WOULD HAVE THE OBLIGATION TO EXPLAIN WHAT KIND OF TREATMENET ADMINISTERED HIM TO TAKE CARE AND TO MANAGE ACCURATELY VERO´S PRECLAMPSIA.REMEMBER:HE ORDERED TYLENOL AND MYLANTA.REMEMBER.HE STATED ND CONSIDERED THE UPPER ABDOMINAL PAIN AS POST PARTUM PAIN.UNBELIEVABLE MEDICAL BLOOPER INDEED!!

JOSEPH Y LI,TWO HOURS AFTER RODRIGFUEZ PRESCRIPTION OF TYLENOL AND MYLANTA ORDERED:A LIQUID DIET AND SOME LAB TESTS (HE ALSO IGNORED BLATTANT SYMPTOMS OF THE PRECLAMPSIA PROGRESSING TO ECLAMPSIA AND HELLP.

TAKE A LOOK OVER THE HOSPITAL ATTESTATION AND SPECIALLY THE PRINCIPLE DIAGNOSIS DATED 7/8/2002

PRINCIPLE DIAGNOSIS: CORD ENTANGLE (IF TRUE IT HAD TO HURT THE BABY NOT THE MOTHER)

THE REST OF POINTS DESERVE AN EXPLANATION COMING FROM THE HOSPITAL AUTHORITIES TELLING US WHAT KIND OF ACCURATE TREATMENT HAS BEEN ADMINISTERED TO MANAGE
PREECLAMPSIA,ECLAMPSIA:SILENCE, OF COURSE ,BECAUSE NO ONE ACCURATE TREATMENT
ALL THE ATTESTED OUTCOMES ARE "DEADLY FINAL OUTCOMES" AND IN THE MEANWHILE, BETWEEN DELIVERY AND STROKE,THERE ARE NON LESS THAN 12 "WASTED"HOURS WITHOUT ANY KIND OF DIAGNOSIS OR TREATMENT.THAT´S WHY VERONICA IS DEAD.

SEE: ON THE CERTIFICATE OF DEATH ,GERONIMO RODRIGUEZ SIGNED: AS IMMEDIATE CAUSE OF DEATH:








miércoles, 18 de noviembre de 2009

HUNTINGTON MEMORIAL "PROPAGANDA" ...LETTER OF OUR FAMILY. TO THE WRONGDOERS





VERONICA SOLANGE GLAUBACH

BORN IN BUENOS AIRES ON SEPTEMBER 12TH/1973
KILLED ON JUNE 30TH/2002
AT THE HUNTINGTON MEMORIAL
HOSPITAL OF PASADENA,CALIFORNIA
MAY SHE REST IN PEACE

WE´LL ALLWAYS REFRESH THE MEMORY OF
THE FOLLOWING IRRESPONSIBLES INDIVIDUALS :

GERONIMO RODRIGUEZ MD.OBGYN
JOSEPH Y LI,MD.OBGYN
MICHAEL GUREVITCH,MD,CCD
CRICKI MORRISEY,RN
ROBIN O BRIEN RN
HILLARY WARREN,RN


ALL OF THEM STILL ON DUTY AT HUNTINGTON MEMORIAL HOSPITAL,PASADENA

IF ALIVE,OUR BELOVED DAUGHTER SHOULD HAVE 36 YEARS OLD AND SHOULD BE ABLE TO TAKE CARE OF INDIANA AGOTE GLAUBACH
HER DAUGHTER ,AND OUR BEAUTY GRANDDAUGHTER
JUST A HAPPY FAMILY AND A NORMAL LIFE..
BROKEN,RUINED LIVES INDEED !

BUT

YOUR CRIMINAL IRRESPONSIBLE AND UNFORGIVABLE MEDICAL IGNORANCE,YOUR GROSS INCOMPETENCE,YOUR SHAMELESS TO CONFESS WHAT YOU DID AND THE INCREDIBLE FAILURES COMMITTED WHILE SHE WAS UNDER YOUR CARE.... SENT OUR DAUGHTER VERO TO THE SKY

THE HUNTINGTON MEMORIAL HOSPITAL PROPAGANDA PROCLAME
“OUR LIMIT IS THE SKY”
WHAT A TERRIFIC TRUE INDEED ¡!

THEY SENT VERONICA STRAIGHT THERE !!!


THE HUNTINGTON MEMORIAL HOSPITAL PROPAGANDA PROCLAME
"MEDICAL MIRACLES HAPPEN AT HUNTINGTON HOSPITAL"
WHAT IRONICAL AND ARROGANT ASSERTION INDEED!.


FURTHER WILLFUL OMISSIONS AND INCONGRUENT MANIPULATION OF THE STRONG AND CLEAR EVIDENCE OF YOUR FAULTS ON THE MEDICAL RECORDS,TO AVOID CONSEQUENCES,WITH THE OBVIOUS COMPLICITY OF THE HOSPITAL SHOWS WITHOUT ANY DOUBT YOUR DEEP AND CRAVEN UNMORALITY INDEED.

THE MEDICAL BOARD-HOOD OF PEERS OF CALIFORNIA AND THE REGISTERED NURSING BOARD-HOOD OF PEERS PROTECTED YOU FROM YOUR MORE THAN DESERVED PUNITION,BUT WILL BE UNABLE TO PROTECT ALL OF YOU FROM YOUR OWN POOR MIND.ALTHOUGH IT´S QUITE PROBABLE THAT YOU DON´T HAVE NOR MIND,NEITHER SOUL

WE WILL NEVER EVER FORGET ALL OF YOU
WE WILL NEVER EVER FORGIVE ALL OF YOU

BY THE WAY:

THE HUNTINGTON MEMORIAL
AUTHORITIES AND THE AFORESAID
INDIVIDUALS NEVER APOLOGIZED
FOR THE KILLING OF VERONICA
EVEN AFTER SETTLING THE CASE

WHAT A NAKED ARROGANCE INDEED !!

ROBERTO THE FATHER,MARTA THE MOTHER, ANDREA,VANESA,NADIA,NICOLE,FIONA,AND ZOE DAUGHTERS OF VERONICA SOLANGE GLAUBACH AND OF COURSE INDIANA AGOTE GLAUBACH,HER DAUGHTER

SHE WILL BE ALIVE FOR EVER !
SHE IS ALIVE TO MAKE WRONGDOERS REMEMBER
ITS CRIMINAL IGNORANT IRRESPONSIBLE BEHAVIOUR INDEED !!!
SHE IS ALIVE AND SHE CLAIMS FOR TRUE AND JUSTICE
REMEMBER,ALLWAYS REMEMBER....REMEMBER FOR THE REST OF YOUR NASTY LIFE !





QUIZ:The Medical Board-erhood of California and Registered Nursing Board-erhood...JUST corruption and anything else..






Veronica and Indiana. Just few hours of Joy. Vero feeding Indiana. Vero,Jose and Indi

This pictures taken around 9,00 am. At 12.00 am started the upper abdominal pain,headaches,blurred vision,swelling legs and hands and nobody at the Huntington Memorial Hospital of Pasadena (suposedly a hi-tec facility),nor nurses Cricki Morrisey,Robin O Brien,Hillary Warren neither Geronimo Rodriguez MD OBGYN or Joseph Y Li MD OBGYN,or Michael Gurevitch MD CCD ,on charge did even recognized those clear symptoms.
Geronimo Rodrigruez prescription: Tylenol and Mylanta !!
Geronimo (Hannibal...)Rodriguez stated that the Upper Abdominal pain was a post-partum pain,while he was in front of a blattant symptom of preclampsia.!!!


Joseph (Animal...) Y Li prescription ordered four hours later,has been just a criminal stupidity and a clear evidence of his wide medical ignoramnce and irresponsibility indeed !!: He signed a prescription of a...Liquid Diet!!!. What else ??? ...In the meanwhile Vero was very close to a fatal stroke
Michael Gurevitch,critical care doctor ,when asked about why a fresh plattelets trasfussion wasn´t administered to our daughter (as wellknown medical standards indicate),stated (Vero was brain dead)in front of many witnesses that the blood of Vero was "rare"...(she was ABRh+).Can anybody believe that assertion ??? I will ignore said imbecility but,however, allow us to ask: is there a blood bank at the famous HI-TEC (they proudly say that" many miracles happen at the Hospital"¿¿ ??? on its advertisings and propaganda on the street in front of the Hospital at Fair Oaks Ave,Pasadena,Ca)???????????. That shameless assertion done by Gurevitch points him as a complete criminal liar and shows in a clear cut a willful shameless intention of mislead .
What for ??
TO HIDE THE TRUE,BECAUSE HE WAS UNABLE TO EXPLAIN THE BRUTALITY OF THE CRIME COMMITTED WITH MY DAUGHTER WHATSOEVER.HE WAS PROTECTING HIMSELF AND THE OTHER INVOLVED WRONGDOERS...AND(OF COURSE) THE HOSPITAL RESPONSIBILITY AS IF HE WERE TALKING TO IGNORANT PEOPLE...BUT WE ARE NOT AT ALL.

THE PUBLIC HEALTH SERVICE REPORT IS TAXATIVE ABOUT THE FAILURES OF THE HOSPITAL,DOCTORS AND NURSESIN THIS CASE.

Allow us to ask to the Medical Board and Registered Nursing Board of California,liers genius "experts"

IS THIS A SINGLE DEPARTURE OF STANDARDS ??? OR IT IS JUST CLEAR MEDICAL IGNORANCE ???
THE CORRUPTED CRITERIA OF THE AFORESAID BOARDS IS NOTHING ELSE THAN PURE CRAP !!!!!

martes, 17 de noviembre de 2009

INDIANA ´s birth weight:under normal and IUGR,denied by Greggory Devore MD,ignored by Dr. Rodriguez ,a clear sign of the mild preclampsia of Vero



To : MEDICAL BOARD OF CALIFORNIA AND REGISTERED NURSING BOARD AUTHORITIES:

HOW CAN YOU SUSTAIN THAT WE ARE FACING DOC´S AND NURSES MANAGING "WITHIN NORMAL STANDARDS" ??? YOU OWE AN APOLOGIZE FOR YOUR INCREDIBLE SHAMELESS INDEED !!!!!
YOU SEEMS TO BE A COLLECTION OF UNSCRUPULOUS BUREAUCREATS: "DOC´S SERVANTS"

Report of the Working Group on Research on Hypertension During Pregnancy

Link: Report of the Working Group on Research on Hypertension During Pregnancy

Pregnancy-related hypertension as related to Hypertension

Link:Pregnancy-related hypertension as related to Hypertension

PRENATAL RECORDS OF VERONICA GLAUBACH SHOWED + 2 PROTEINURIA,AMID OTHER CLEAR SYMPTOMS.THE MEDICAL BOARD OF CALIFORNIA NOTWITHSTANDING EXPERTS REPORTS POINTING A GROSS CASE OF MALPRACTICE,CONSIDERED THAT GERONIMO RODRIGUEZ MD,OBGYN,PASADENA,JOSEPH Y LI,MD,OBGYN,PASADENA AND MICHAEL GUREVITCH,MD,CCD,(HUNTINGTON MEMORIAL HOSPITAL) DID NOT COMMITTED ANYTHING ELSE THAN A "SINGLE DEPARTURE FROM STANDARDS" A BARGAIN CLAUSE INSERTED ON THE MEDICAL PRACTICE ACT OF THE BPCODE TO PROTECT DOCTORS.THAT SINGLE DEPARTURE WAS "NOT HAVING ORDERED A URINE TEST" NOTWITHSTANDING HUGHE EXISTING WARNINGS ON THE PRENATAL RECORDS,+2 PROTEINURIA,HBP,PAIN,SWELL,LIGHT SPOTS SEEING,ETC ETC,AND EVEN AFTER READING TERRIBLE LAB TESTS SHOWING AN UPCOMING COAGULOPATY DUE TO THE INCREDIBLE LOW NUMBER OF BLOOD PLATELETS.BLOOD TRANSFUSSION ?; NEVER PERFORMED.....DIAGNOSIS?:INEXISTENT ON TIME ONLY AFTER DEATH.
WHAT IS THE MEDICAL BOARD OF CALIFORNIA VALUE TO PROTECT HEALTH CARE QUALITY ???? : +0(CERO)

Coding for Pregnancy-Related Hypertension

Link: Coding for Pregnancy-Related Hypertension

Preeclampsia Causes, Symptoms, Diagnosis, and Treatment on MedicineNet.com

Link: Preeclampsia Causes, Symptoms, Diagnosis, and Treatment on MedicineNet.com

VERONICA´S CASE. A GROSS FAILURE TO DIAGNOSE DONE BY TWO IRRESPONSIBLES AND IGNORANT DOC´S GERONIMO RODRIGUEZ MD,OBGYN AND JOSEPH Y LI,MD,OBGYN AND THE COMPLICITY OF A THIRD ONE MICHAEL GUREVITCH,MD AT THE HUNTINGTON MEMORIAL HOSPITAL,PASADENA,CA
THIS WRONGFUL DEATH DUE TO MEDICAL"IGNORANCE"MALPRACTICE REMAINS WITHOUT SANCTION AGAINST THE AFORESAID WRONGDOERS DUE TO THE COMPLICITY OF THE WIDE CRITICIZED AND USELESS MEDICAL BOARD OF CALIFORNIA.IN ADDITION THREE NURSES INVOLVED ARE STILL WORKING BECAUSE THE REGISTERED NURSING BOARD OF CALIFORNIA,ANOTHER USELESS AND CORRUPTED BOARD RECENTLY DENOUNCED IN A SERIES OF ARTICLES BY CHARLES ORNSTEIN AND TRACY WEBER,LATIMES,JULY 11TH 2009,PROTECT WRONGDOERS AS WELL.


The following article points out which are the symptoms of PREECLAMPSIA.
All of them were present in Veronica.All of them ignored by Doctors and Nurses.
That´s why she died without any kind of accurate treatment.
That´s why we face a blattant case of MEDICAL FAILURE DUE TO MEDICAL IGNORANCE.



THAT´S WHY I BLAME THE MEDICAL BOARD OF CALIFORNIA AS USELESS AND CORRUPTED
THAT´S WHY THE MEDICAL BOARD IS GUILTY OF WILLFUL OMISSION IN COMPLICITY WITH CRIMINALLY IGNORANT PHYSICIANS JUST TO PROTECT THEM FROM THE DUE DISCIPLINARIAN ACTION.MEANWHILE,THE PEOPLE DIES EVERY DAY AND THOSE INDIVIDUALS(TOTALLY UNSKILLED) ARE STILL ATTENDING INOCENT PATIENTS,ALL OF THEM POTENTIAL VICTIMS OF THEIR CRIMINAL FAILURES.


lET´S see:

Mayo Clinic Health Manager

Symptoms
By Mayo Clinic staff

Preeclampsia can develop gradually but often attacks suddenly, after 20 weeks of pregnancy. Preeclampsia may range from mild to severe. If your blood pressure was normal before your pregnancy, signs and symptoms of preeclampsia may include:

* High blood pressure (hypertension) — 140/90 millimeters of mercury (mm Hg) or greater — documented on two occasions, at least six hours but no more than seven days apart
VERONICA HAD NOT ONLY 140/90 BUT MUCH HIGHER THAN THAT.

* Excess protein in your urine (proteinuria)

VERONICA SHOWED +2

* Severe headaches

VERONICA HAD UNBEAREABLE HEADACHE ,Geronimo Rodriguez,MD ,OBGYN
prescription has been :Tylenol and Mylanta

* Changes in vision, including temporary loss of vision, blurred vision or light
sensitivity.

VERONICA SAW SPOT LIGHTS AND BLURRED VISION

* Upper abdominal pain, usually under your ribs on the right side

VERONICA WAS UNABLE TO SUPPORT AN UNBEAREABLE UPPER ABDOMINAL PAIN
GERONIMO RODRIGUEZ PRESCRIPTED: TYLENOL,MYLANTA AND FINNALY VICODIN
HE CONSIDERED THAT PAIN ASX A POST PARTUM PAIN
ANOTHER DOCTOR.JOSEPH Y LI MD OBGYN WHO SAW VERONICA LATER
PRESDCRIPTED A LIQUID DIET !!!(sHE WAS GOING STRAIGHT TO DEATH AT THAT
POINT !!!)


* Nausea or vomiting

VERONICA VOMITED EVERYTHING: THE TYLENOL,MYLANTA ETC-TERRIBLE NAUSEA
* Dizziness
* Decreased urine output
* Sudden weight gain, typically more than 2 pounds (.9 kilograms) a week

Swelling (edema), particularly in your face and hands, often accompanies preeclampsia. Swelling isn't considered a reliable sign of preeclampsia, however, because it also occurs in many normal pregnancies.

VERONICA SUFFERED EDEMA (FACE AND HANDS AND LEGS)

AND THE WORSE:ALL OF THESE SYMPTOMS WERE POST PARTUM.VERONICA WAS CRYING.VERONICA
WAS DYING.NOBODY AT THE HUNTINGTON MEMORIAL HOSPITAL(NEVER GAVE AN APOLOGY TO US)
DID ANYTHING ACCURATE WHEN IT WAS TIMELY TO SAVE HER LIFE.THEY IGNORED EVERYTHING.
HOW CAN THE MEDICAL BOARD OF CALIFORNIA AND THE REGISTERED NURSING BOARD OF CALI-
FORNIA,SUSTAIN THAT IT WAS JUST A MISTAKE OF RODRIGUEZ AND LI,JUST A SINGLE
DEPARTURE OF STANDARDS????? WHEN ITS A CLEAR CASE OF MEDICAL IGNORANCE,INCOMPETEN
CE AND NEGLIGENCE'''''???? THE CYNICISM OF THE BOARDS REVIEWERS AND AUTHORITIES IS
NOT ONLY A PERVERTED BEHAVIOUR,IT IS VERY DANGEROUS FOR THE HEALTH CARE QUALITY
INDEED!



When to see a doctor
Contact your doctor immediately or go to an emergency room if you have severe headaches, blurred vision or severe pain in your abdomen.

Because headaches, nausea, and aches and pains are common pregnancy complaints, it's difficult to know when new symptoms are simply part of being pregnant and when they may indicate a serious problem — especially if it's your first pregnancy. If you're concerned about your symptoms, contact your doctor.
Causes Definition
References

1. Pregnancy. National Heart Lung and Blood Institute. http://www.nhlbi.nih.gov/hbp/issues/preg/preg.htm. Accessed March 3, 2009.
2. Conde-Agudelo A, et al. Maternal infection and risk of preeclampsia: Systematic review and metaanalysis. American Journal of Obstetrics and Gynecology. 2008;198:7.
3. Bodnar LM, et al. Maternal vitamin D deficiency increases the risk of preeclampsia. The Journal of Clinical Endocrinology & Metabolism. 2007;92:3517.
4. High blood pressure during pregnancy. March of Dimes. http://www.marchofdimes.com/printableArticles/188_1054.asp. Accessed Feb. 11, 2009.
5. Norwitz ER, et al. Management of preeclampsia. http://www.uptodate.com/home/index.html. Accessed March 2, 2009.
6. Leanos-Miranda A, et al. Urinary prolactin as a reliable marker for preeclampsia, its severity, and the occurrence of adverse pregnancy outcomes. Journal of Clinical Endocrinology Metabolism. 2008;93:2492.
7. Fact sheets: High blood pressure during pregnancy. March of Dimes. http://www.marchofdimes.com/printableArticles/14332_1222.asp. Accessed Feb. 11, 2009.
8. August P, et al. Clinical features, diagnosis and prognosis of preeclampsia. http://www.uptodate.com/home/index.html. Accessed March 2, 2009.
9. Barton JR, et al. Prediction and prevention of recurrent preeclampsia. Obstetrics & Gynecology. 2008;112:359.
10. Bellamy L, et al. Pre-eclampsia and risk of cardiovascular disease and cancer in later life: Systematic review and meta-analysis. British Medical Journal. 2007;335:974.
11. Facchinetti F, et al. Migraine is a risk factor for hypertensive disorders in pregnancy: a prospective cohort study. Cephalgia: An International Journal of Headache. 2009;29:286.

DS00583

April 21, 2009

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Pregnancy problems. Complications | Woman's Passions

Link: Pregnancy problems. Complications | Woman's Passions

How Common Is High Blood Pressure In Pregnancy? | urine blood causes

Link: How Common Is High Blood Pressure In Pregnancy? | urine blood causes

Pregnancy-related hypertension - Blogs

Link: Pregnancy-related hypertension - Blogs

Blood biomaker to predict preclampsia

New Study Heralds Use of Blood Biomarkers to Predict Preeclampsia

November 17, 2009 by admin

A new study that examines the value of maternal blood biomarkers will help identify and monitor patients at risk of developing preeclampsia and is set to change the way expectant mothers are cared for in prenatal clinics around the world.

The study, conducted by scientists at the highly-respected National Institute of Child and Human Development of the National Institute of Health (NICHD/NIH), set out to determine the diagnostic indices and predictive values of biomarkers measured in maternal blood in the first and second trimester of pregnancy. The goal of the study was to determine if the biomarkers could predict the subsequent development of preeclampsia.

“This study represents a very important step forward; for the first time ever, we are presented with the possibility, for clinical use, of a combination of factors to predict early onset preeclampsia with a reasonable degree of accuracy,” says Professor Marshall Lindheimer, Professor Emeritus of Medicine and Obstetrics & Gynaecology at the University of Chicago.

Preeclampsia is the leading cause of infant death and the second leading cause of maternal death Around the world. Conservative estimates indicate that preeclampsia is responsible for some 76,000 maternal deaths and more than 500,000 infant deaths every year, according to the Preeclampsia Foundation. Early onset preeclampsia is the most dangerous form of this disease.

Known worldwide as ‘the silent killer’, preeclampsia is a disorder that occurs during pregnancy and after delivery. It is characterized by high blood pressure and the presence of protein in maternal urine. However, preeclampsia can affect other organs such as the liver, the kidney, the brain. Sometimes mothers develop seizures (eclampsia) and have intracranial haemorrhage which is the main cause of death. In some instances, women develop blindness when preeclampsia is severe. They may also suffer catastrophic complications such as liver rupture.

The findings of this new study are published in the November issue of the Journal of Maternal-Fetal & Neonatal Medicine.

“Left untreated, preeclampsia leads to serious - or fatal - complications for both the mother and baby,” says Dr Kusanovic of the Perinatology Research Branch of the NIH and Wayne State University/Hutzel Women’s Hospital in Detroit, Michigan and lead author of the study.

“Our study found that maternal plasma concentrations (of angiogenic and antiangiogenic factors) together with a combination of other demographic, biochemical and biophysical factors are useful in assigning risk for the subsequent development of early-onset preeclampsia,” explains Dr Roberto Romero, Chief of the Perinatology Research Branch of the NIH, who is one of the world’s leading experts on this condition and in the study of complications of pregnancy.

“The establishment of an accurate means to assess the risk for preeclampsia will enable health care practitioners to identify women who require more intensive monitoring to safeguard both mother and baby from this devastating condition,” says Dr Romero.

Dr Mario Merialdi, Coordinator for Improving Maternal and Perinatal Health at the World Health Organisation (WHO) said: “The results of the study conducted by the international team led by Dr Romero have important implications for clinical practice and public health policies. Hypertensive disorders of pregnancy are one of the major causes of maternal and fetal mortality worldwide.”

“Reliable screening tests that could identify women at risk for developing preeclampsia are not yet available and the findings of Kusanovic et al. provide the scientific basis for the development of such tests,” explained Dr Merialdi.

“The World Health Organization, in collaboration with the Perinatal Research Branch of the NICHD, is presently analyzing samples collected in more than 10,000 pregnancies in eight countries around the world to further validate the results obtained by Dr Romero’s scientific team.”

Informa - publishers of the Journal of Maternal-Fetal & Neonatal Medicine - has made the full article available for open access on its website and invites visitors to log onto: http://informahealthcare.com/doi/abs/10.3109/14767050902994754

SOURCE Journal of Maternal-Fetal & Neonatal Medicine
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lunes, 16 de noviembre de 2009

see. malpracticeincalifornia.the killing of veronica

see my other blog:: veronicaglaubachmalpracticeinusa.blogspot.com

THE MEDICAL BOARD OF CALIFORNIA AUTHORITIES ARE SIMPLY PUBLIC SERVANTS.THEY HAVE TO ACCOMPLISH ITS DUTIES

I am still awaiting that Mrs Jaroslavsky and Mrs Johnston honor her quality of PUBLIC SERVANTS.THEY HAVE TO GIVE AN ANSWER TO MY LAST REQUE4ST OF FULL REDOING OF ALL,having into account the evidence and the incongruent last report signed by the Medical Board.
I will sustain this complaint FOR THE REST OF MY LIFE,and each day will grow and grow untill they will not be able to avoid a public explanation .No matter how long will be my insistence or how long will they turn her faces to the other side to avoid her unavoidables duties as what they really are:simply PUBLIC EMPLOYEES but with heavy responsibilities. The main responsibilitie: TELL THE TRUE INDEED!!!!!!!

LAST CLAIM TO THE MEDICAL BOARD-STILL WITHOUT RESPOND FROM MRS BARB JAROSLAVSKY BARB JOHNSTON BOARD DIRECTORS..SEEMS THEY ARE COLD PEOPLE INDEED !!

Buenos Aires,September 17,2009

REF.11-2003-144255
11-2003-144256
11-2005-166043
PHYSICIANS. GERONIMO RODRIGUEZ,JOSEPH Y LI AND MICHAEL GUREVITCH

FACILITY:HUNTINGTON MEMORIAL HOSPITAL,PASADENA COMPLAINT CA 00034156 COUNTY OF LOS ANGELES DEPT OF HEALTH SERVICES,HEALTH FACILITIES DIVISION.
Buenos Aires,September 17,2009

To :
The Medical Board of California
Mrs Barbara Jaroslavsky
Barb Johnston
Renee Threadhill
Att: Mrs Susan Cady
cc. Gov.Arnold Schwartzenegger´s office
cc. Charles Ornstein Pro Publica org.
cc. David Gumpert


“ You can have good health insurance,live in a community with state of the arts facilities and yet none of that matters if you can´t find a doctor,or the doctor treating you is incompetent,negligent or dishonest. That´s why medical boards matter”…Barb Johnston,may 7,2009

“The most crucial step toward healing is having the right diagnosis. If the disease is precisely identified, a good resolution is far more likely. Conversely a bad diagnosis or the absence of diagnosis generally jeans a bad outcome , no matter how skilled the physician is. Healing begins with the correct diagnosis”..

THE KILLING OF VERONICA, is a clear case of wrong diagnosis (lack of it ) originated in a mix of incompetence and negligence of doctors and nurses worsened by the hospital´s further complicity to veil the true facts.Moreover,after realizing the mess,the involved physicians concealed the evidence of their failures.The prenatal records and all the symptoms were blatantly clear to any skilled professional. Not in this case.


This letter is to reply your attached letter dated July 15,2009 and at the same time to insist once more with my request of a complete and fairer revision over Case 11-2003-144255 and Case 11-2003-144256.Geronimo Rodríguez MD and Joseph Li MD, both OBGYN who I blame as main responsibles of the death of my 28 years old daughter Veronica Solange Glaubach at the Huntington Memorial Hospital,Pasadera,on June 30th 2002,at the age of 28 .

I will expose and point out in a clear cut the reasons which will sustain and explain my insistence in pursue a disciplinarian action to be taken against those irresponsible and unskilled physicians .

Mrs Cady: as you explain in your letter,the Board must be able to obtain the whole necessary information …etc…etc ..within seven years of the date of the incident,according BPCODE Section 2230.5, it´s true,but,it doesn´t fit to this case. Why ? , because in my complaint,timely submitted, I am reporting not only a medical malpractice case, because at the same time I´m accusing Rodríguez and Li for unfair procedures as a furtherance of their failures.

That´s mean: unprofessional conduct based on incompetente,gross negligence and worse of all willful and intentional actions in order to conceal from discovery his failures as even the most distracted analyst can easily realize just taking a simple but thorough look over his hypocritical ,coward and prevaricant discharge summary, our experts discovered indeed.

Just contrasting said “discharge summary” with the death certificate,signed by Rodríguez,and with the contradictoty and misleading hospital´s attestation report,even the most dull witted analyst will clairly see the flagrant existent contradictions which I have to attribute to the urgency with which they runnned (hospital authorities+nurses+doctors) to conceal, to mislead and to hide the true events after the death of Veronica.

I was pressing requesting in a firmly manner at the medical records office to full copy of medical records,which they gave to me,at last,but in the most incredible disorder which leaded me to go inside the office and to work there for at least six hours to organize those papers ant to assemble big flowsheets. Late,very late,those “papers” whose the hospital is “custodian” were been already “touched” Well Mrs Cady,it seems that they committed errors again.That simple indeed

The Board spent almost three years (just a little delay ¿??) to investigate (or whatever) this clear case of medical malpractice. Just to compare: The Public Health Service spent no more than six months to conduct a thorough depth investigation and to submit it conclusions. The same documentation and witness reports has been given to the PHS and to the MBC.

Mr Alan Irish can state how many times I´d been going to Diamond Bar to provide elements germane to this case.Same as Dave Thornton and former President Ron Wender, and DAG Robert Mc Kim Bell ,so I am absolutely “on time” having into account the unacceptable delay of the Board to insist in my request of true and decency and disciplinarian actions against the aforementioned wrongdoers.

The California Department of Health Services,declares in a ten pages summary signed by Marlene Taylor Chief of HFD and Eric Stone,Supervisor AAU:…” A review of the closed medical record revealed that the diagnosis of hipertensión in pregnancy,preeclampsia/eclampsia and HELLP síndrome were absent from MD 1´s discharge summary despite documentation of these syndromes by MD 1 in the medical record and that they were the critical events and conditions that led to the patient´s death”.

MD1 is ,of course, Mr Gerónimo Rodríguez, Why ?..because he signed the aforesaid discharge summary.

Which has been the diagnosis signed by Rodríguez ?

“Disease due to failure to cardiorespiratory system due to brain hemorrhage”

So it seems that my poor daughter died due to a brain hemorraghe ,yes,it´s true,if you want,..,but that was the last outcome of the store: an inexistent diagnosis and as a logical consequence of said inexistent diagnosis, the absence of any timely accurate treatment to manage the sickness. That´s why my daughter went to the sky.

About the “failure of cardiorespiratory system”… it doesn´t deserves any further comment.Everybody knows that people dies due to the aforesaid failure.A real stupidity.

Why did Rodríguez remain silent and avoided to state and sign the correct diagnosis of preclampsia/eclampsia/Hellp ? It´s quite simple. Because by signing the aforesaid diagnosis (lately realized by Gurevitch not for him) he was admitting his wide incompetence and gross negligence since he never ordered any accurated treatment to manage preeclampsia,eclampsia or Hellp indeed..

So Rodríguez (maybe in combination with Li and some authorities of the Huntington ¿?) decided to mislead and conceal his lack of ability ,to mislead further investigations,shading the true facts, in short :he lied. What for ¿ To avoid disciplinarian consequences.
That´s why this case is not subject to the limitation provided for by subdivision a) pursuant to Section 11503 of the Government Code as it apppears on paragraph (c) on BPCode Section 2230.5

It´s quite clear that the Medical Board didn´t take into account the dishonest action performed by Rodríguez on his signed prevaricant summary and related documents, which in my humble opinión means that this case is uncomplete whatsoever .

The Medical Board of California is owing us explanations about this incongruent and false discharge summary,and about the other existing incongruences and contradictions emerging from the documentation.


But,we still have many other details concerning this complaint:

Let´s see:
Rodríguez signed his false discharge summary on July 2nd,2002 on which he mentioned “cord entangle” without giving relevance to said situation ,he stated: “..cord around the neck was seen..” Its clear that “cord around the neck is germane to the baby situation. Nothing to do with my daughter´s preeclampsia in progress , eclampsia or further HELLP and death as well.

On July 7th,2002, Rodríguez signed a death certificate stating as immediate causes of death:

1.- Cardiorrespiratory Arrest
2.- Intracerebrum Hemorrhage
3.- Hellp

The Hospital´s final diagnosis written in the “attestation report” of July 8,2002 has been the following:

Principle Diagnosis: Cord entangle neck (¿?)
If cord entangle neck (a stupidity) was the principle diagnosis recognized by the Hospital authorities as main circumstance which developed to Hellp,you need no further analysis to conclude that nor Rodríguez nor Li,neither nurses or whoever,did any accurate diagnosis. We face contradictions and incongruences one after another.Pure Lies.

Secondary Diagnosis:Cerebrovasculart disease (consequence of HELLP))
Coagulation deficiency (consequence of HELLP)
Severe preeclampsia .

Allow me to ask: Severe preeclampsia stated by the hospital,?? But where is the Hellp stated by Rodríguez on his summary ¿? And why he signed hellp on the death certificate ¿? Who told rodríguez that it was a Hellp ¿?



Why the hospital statement postulates a “ severe preeclampsia “as secondary diagnosis ? ..,because only Gurevitch started a slight procedure to try to stop the outcoming drama when my poor daughter,medically abandonned ,was irremediably out of any hope. Previously to that point, for instance Li was prescripting a liquid diet . Do you need more proofs ¿???


It is more than clear the existing incongruences between Rodríguez discharge summary,the death certificate signed by him and the hospital´s attestation report .Same pattern of default of honesty and decency to avoid responsibilities.

It seems that Rodríguez discovered the real diagnosis five days after the death of my daughter, It seems… or …are we facing another incongruent lie (having into account what he signed on the aforesaid summary ¿?One lie after another lie.

Let´s analyze the rest of the aforesaid “untruthful “discharge summary:

Rodríguez stated that at the time of admisión (01.20 am) blood pressure was: 133/86 (which is high) and… nothing else was remarkable. Did Rodríguez take even a quick look over the prenatal records ¿? The prenatal records are full of clear warnings and concerns about preclampsia,preterm labor, IUGR, proteinuria+2 and HBP all symptoms of a mild preclampsia ,a big signal notifying to everybody that Veronica was a “high risk patient” indeed.
Moreover ,when admitted Veronica mentioned to have seen spots the previous day. What else ¿?

Blood pressure at 03.00 am 142/91
Blood pressure at 03.32 am 151/91
Moreover: at 04.10 am it´s written: she had alive reflexes,which are clear symptoms of neurological disturbance

At 06.48 Veronica gave birth to my granddaughter who weighted 2029 grams,thats a clear sign of IUGR and even all the aforesaid symptoms Rodríguez did not considered the possibility of preclampsia.

At 6.50 she vomited 100cm3 of clear liquid.
Where are the instructions given by Rodríguez to make specific and more rigorous chekups on my daughter ¿? They do not exist.

Blood pressure at 07.00 am 148/92
Blood pressure at 07.15 am 148/97
Blood pressure at 07.45 am 138/75
Blood pressure at 08.00 am 153/83
All the blood pressure levels were abnormals,all the time:

Notwithstanding the aforementioned high blood pressure levels we can read
The entry signed by Rodríguez on the Hospital Course: Laboratory initially was done,as I mentioned,because the blood pressure was “ somewhat elevated,although the patient was completely asymptomatic and denied any headache,blurry vision or epigastric pain”….

What means “somewhat elevated”? A little elevated,less elevated ¿??
High blood pressure is anything else than that: high blood pressure. Our experts felt astonished reading that outrageous explanation indeed. All the blood pressure levels has been abnormals,all the time.-


What is the worse:….the patient was completely asymptomatic and denied any headache,blurry vision or epigastric pain”….this assertion is another big lie,but at the same time it unveils a real true.Let´s see:

Rodríguez assertion that Veronica was asymptomatic is anything else than a complete recognition of his wide ignorance about symptoms germane to the existing eclampsia in progress to hellp since he was watching -but not recognizing- clear symptoms saiod pathology.

At the same time he is lying since Veronica mentioned having seen spot lights and complained about headaches,terrible unbearable upper abdominal pain,suffered nausea,vomits and her hands and legs showed edema.

The California Dep..of Health Services statement indicates:…”A review of the closed medical record revealed an incomplete and unsigned physician´s Progress Note on June 30th,2002 at 6.03 am “….Further review of the closed medical record revealed that the physician´s Progress Note on June 30,2002,entered after the Progress note of 7PM couyld not be read and the signatura cannot be identified. The same handwriting was found in a Progress Note on July 1,2002 for which no time of entry was documented”…

…” a review of the closed medical record revealed that MD 2 (Li) did not indicate the time of his note on June 30,2002”
…” a review of the closed medical record revealed that a Physician´s order on July 1,2002 at 06.16 am was not signed”…

…” Although an autopsy was not performed,( it´s been declined by an e-mail signed by Dr Lois Pena who never saw the body ) the record review revealed that the patient was hypertensive throughout her hospital course untill hours before her death.The clinical diagnosis were Eclampsia and Hellp Syndrome”…(diagnosis ignored by Rodríguez on his discharge summary)

Rodríguez states on the summary:…”Then the patient went to the floor.In that area at approximately 12 in the afternoon the nurse called saying the patient was having vomiting.She vomited the Tylenol #3 and seemed like she had some gastritis and that time Mylanta was ordered (by whom ¿?)and DC´d Tylenol and give her vicodin and they believed (who believed ¿? Nurses ¿?)) that perhaps the codeine produced her gastritis”…

This statement is an absolute lie. One of the nurses suspected that the symptoms were germane to preclampsia and she did informed Rodríguez about said concerns.

Veronica was accompanied by her mother and her boyfriend.They witnessed everything.Nurses also. At 12.15 am Veronica had a growing and unbeareable epigastric pain.,nausea,saw spot lights,showed edematic hands and legs,She was given Tylenol which she vomited right away.It seems that Rodríguez ordered Tylenol and Mylanta telling the nurses (by telephone because he was absent) that it was a post partum pain (what is expected in puerperium is perineal pain not epigastric pain).

Rodriguez ordered additionnaly Vicodin which she vomited as well.Vicodin is a narcotic analgesic (hydroxycodone). Medically,narcotics analgesics are not indicated for a patient suffering from usual labor pain but for a thorougly different symptoms,unrelated to organs envolved in labor process.

Another proof of medical ignorance ant the total disorientation of Rodríguez.He was attacking the pain not the causes. Why ¿? Because he never identified the sickness which was producing said symptoms indeed.


On the contrary,what world have been advisable was to be on guard considering that those symptoms were the most frequent of HELLP syndrome (65% of cases).In addition: in the Clinical resume there is no record of investigations carried out due to epigastric pains.


Thereafter,Rodríguez abandoned the patient for a long long while almost three “golden” hours.Several attempts to contact Rodríguez were absolutelly unsuccesful.In spite of having being paged once and again Rodríguez has been all the time unavailable and out of reach or else he has been always late.

Not only has he always been late or absent but also he has not even dared to enter any entry in the medical records and clearly enough he had left the case in the hands of the registered nurses without even giving a diagnosis .
After 14.30 pm till 18.00 pm there is a total absence of entries in the medical history.

As Rodríguez was out of reach,Li had to be called in emergency (he atended Veronica during pregnancy so he must know her prenatal records indeed).He ordered some lab tests and a stupidity: a liquid diet(¿? What for) and a vial of Demerol to calm pain.He never inquirid or investigated the real cause of that upperabdominal pain,whose cause remained without any explanation.
There you have another demonstration of medical incompetence


Rodríguez and Li knew the results of blood tests ordered at 16.05.Platelets showed a dangerous low lever of 119.000 mm3. All studies are coincidental :platelets below 150.000 mm3 shall cause great concern about Hellp.They saw that result but haven´t done any accurate managment :v.g .a platelets transfusión for example.

So: of what single departures are you talking about ¿?

The Board´s final conclusión about Rodríguez and Li is outreageously and daringly unacceptable and it offends and underestimates the inteligence of any skilled and trained doctor or/and any forensic witness expert.

It is by far clear that Rodríguez failed by far in much more than to order a simple urine protein determination.,as the board´s states.He failed to diagnose,(he didn´t diagnose),thereafter he failed to recognize any single symptom of the progressing eclampsia,he abandoned the patient,he lied and falsified his report to conceal his own ignorance from discovery and experts are strongly concerned about the missing sheets of the medical records and many obvious incongruences on statements and entries.

About the other wrongdoer Li,the board´s final report:…” …he failed to properly evaluate Veronica´s complaint by reviewing the medical records.The persistent complaint of epigastric pain (without an alternative diagnosis..??)should have prompted therapy with magnesium sulfate..” shows the same pattern of irresponsible indulgence and a wide distortion of the true .

The real true is that nor Rodríguez neither Li took a minnimum single look over the records (pre natal and hospital recordsas well) and both of them ignored the upper abdominal unbearable pain germane to eclampsia,so they never started any therapy with Mg sulfate.Mg sulfate has been administered just when it was very late.

As(renowned) forensic expert Dr Ricardo Bocacci reported, (I attach with this letter the full report) Dr Gurevich was the first one to wonder about the possibility of preeclampsia during pregnancy but it was very late (19.00 pm) but Veronica was already out of any hope.Late very late.

The Board´s conclusion seems to be aimed to protect those two dangerous negligent and incompetent wrongdoers.Experts are absolutely coincidental about the lack of ability and their further intentional misleading and concealing behaviour.

The Board spent almost three years to investigate this clear case of medical malpractice. The Public Health Service spent no more than six months to conduct a thorough depth investigation and to submit it conclusions.Same documentation and witness reports has been given to the PHS and to the MBC,moreover,Mr Alan Irish knows how many times I´d been going to Diamond Bar to provide elements germane to this case.Saqme as Dave Thornton and former President Ron Wender,so I am absolutely “on time” to insist in my request of true and decency and disciplinarian actions against the aforementioned wrongdoers.

By the way: Your qualification of “single departure from standards” is unsustainable from every point of serious view.,no matter what kind of interpretation you give to that “bargain clause” a big “black hole” of the
MPAct of BPCode. Anything ,I repeat anything can be framed with the aforesaid definition.Not in this case.

When I say “bargain” I know (as you know) of what I´m talking about. Said definition (bargain) was given to me at the office of former Senator Sheila Kuhel
I mean:she knows of what is talking about.

A copy of this letter will be sent to Governor Arnold Schwartzenegger´s office and to LATimes investigative reporter Charles Ornstein autor of “When caregivers harm” …Veronica Glaubach Joy of birth,then drama ,and to David Gumpert,maybe the next investigative report should be:”When Medical Board harm ¿?”

I demand true and justice. Just human rights Nothing else.

Roberto A Glaubach,
The father of Veronica
Architect



The following report ,which is by far very clarifying, is the transcription of the original signed by Ricardo Boccacci,MD,forensic,expert before The Supreme Court of Justice,a wellknown pathologist, and clinical expert with almost 40 years of expertise and international experience.


A) BACKGROUND: PREECLAMPSY

The patient Veronica Solange Glaubach was having a high-risk pregnancy due to several indicators of preeclampsy, namely:

1. She had positive albuminuria type 1 on June 8th and 25th and type 2 on June 11th. In general, proteinuria is the last sign to appear in preeclampsy and therefore, such sign is of highly clinical importance.(pages 1-2)


2. According to checkups made on her during pregnancy, levels of blood pressure were of 90/60 and 100/70 as from January 9th till May 1st and 112/70, 112/68, 110/70, 100/60, 116/70 as from March 21st till June 25th what clearly shows that the patient had a caracteristical basal hypotension . When she went into the Hospital, the levels of blood pressure increased significantly : on June 30th . 01.20 blood pressure was of 133/86; 04.10 am : 140-150/80- 90 mm Hg. Although there exist several definitions of preeclampsy, many describe it as clinical symptoms with tensional levels above 140/90 mm Hg , an increase of systolic blood pressure of 30 mm Hg or an increase of the diastolic blood pressure by 15 mm Hg after week 20 together with proteinurea in excess of 300 mg during the 24 hours. It is obvious that Verónica had all to fit that diagnostics.(page 3)


3. Moreover, it is important to point out that in the pre-natal control flow sheets you can read several times that precautions must be taken. Shall I ask you why?(pages 1-2-3)

4. When she got into the Hospital, it has been written in the Maternal Clinical Resume that the reports of pre-natal controls had been noticed. In such reports you can read in several places the existence of proteinurea and the need of taking precautions . Notwithstanding, in the Clinical Resume there is no reference that such warnings had been communicated to the doctors in charge. (page 4)

5. From the moment Verónica got into the hospital , she had shown high tensional values and mentioned to have seen spots on the previous day. Moreover, at 04.10 it`s written,she had alive reflexes.,symptoms of neurological disturbance. At 06.50 she vomited 100 cm3 of clear liquid . However, these symptoms didn’t arise any concern to the medical staff in charge so that nobody gave instructions to make specific or more rigorous checkups on the patient, being no record that this abnormal symptoms have been informed to any of the doctors in charge. (page 5)

6. At 6.,48 Verónica gave birth to her daughter who weighted 2029 grams . There exist several definitions for I.U.G.R. (retarded intrauterine growth ). However, most of the doctors agree to define I.U.G.R. as less than 10 percent of predicted fetal weight for gestational age. In general , any birth in term with the newborn weighting less than 2.500 grams implies an I.U.G.R. Now my question is, considering the weight of the newborn baby , nobody of the medical staff considered the possibility of preeclampsy? (page 6)


B) LACK OF ADEQUATE POSTPARTUM CONTROL–ONSET OF

ECLAMPSY – H.E.L.L.P. SYNDROME:

1. The labor which in the medical staff view required precautions, took place on June 30th. at 06.48 . However, the next record was only made at 09.00 indicating breastfeeding without any mention of the health of the parturient.(page 7)


2. In all Obstetrics services, it is wide known that immediate puerperium must be strictly surveyed, mostly during the first two hours , putting emphasis on heavy bleeding, frequency of the pulse, blood pressure, and uterine involution. Such controls must be made each 15 minutes. Pursuant the post anesthesia recovery data sheet , blood pressure has been controlled each 15 minutes and levels were all abnormal , worrying and unrelated to the levels the patient had shown during pregnancy and that were registered in prenatal control data sheets: at 7.00 blood pressure of 148/92; 7.15 – 148/97; 7.30 – 138/5 ; 7.45 – 148/76 and at 8.00 –153/83. Notwithstanding this abnormal tensional increase, there is no mention of it in the Patient Progress Record so as there is any mention of actions taken by doctors or registered nurses to clarify this anomaly. In fact, the Patient Progress Record goes from the record taken at 6.31 when Dr. Rodriguez arrived to the corresponding verification of birth taken at 6.48 , and from there to the record of no breastfeeding taken at 9.00 and to “growing epigastric pain” at 12.15. In short , for more than six hours , there have been no statements regarding the medical condition of the patient, her blood pressure, diuresis, uterus involution, etc.
In the Progress Record the situation is worse though, there is no record till the intervention of an obstetrician in emergency[2].. This means that from the medical staff point of view the patient almost did not exist : she was a problem ascribed to the registered nurses.
However, it is clear enough that five from eight records of systolic blood pressure taken between 7.00 and 8.00 were within hypertensive range, same as two of those of diastolic blood pressure. (page 7-8-9)


3. The lack of controls and negligence are obvious also in the Maternal Flow Sheets because there are sporadic records of the levels of blood pressure taken at 03.00, 04.00, 05.00 and 06.00 being all of them abnormals 142/91, 139/50, etc. However, next register is only at 09:00 – 140/56 and the next one at 12:00 – 170/55 , that is to say three hours later. Pain level is also therein registered but only at 11:00, 12:00 and 14.:00. At 12:00 she was administered Vicodin and at 14:00, Demerol.


4. At 12:15 Veronica had a growing epigastric pain . She was given Paracetamol, an unespecified anesthetic (Tylenol) which the pacient vomited right away. What is expected in puerperium is perineal not epigastric pain. Nobody cared for this symptom which is in fact one of the first symptoms to appear when HELLP onsets. (page 7)


5. Faced with a growing epigastric pain and vomits , Dr. Rodriguez administered Mylanta (antiacid) and narcotic analgesics (hydroxycodone) whose commercial name is Vicodin , what she immediately vomited as well. Medically, narcotic analgesics are not indicated for a patient suffering from usual labor pain but for a thoroughly different symptoms, unrelated to organs or structures involved in labor process. On the contrary, what would have been advisable was to be on guard considering that those symptoms were, as aforementioned , the most frequent of HELLP syndrome(present in 65% of the cases). In the Clinical Resume there is no record of investigations carried out due to epigastric pains.


6. With growing pain, sickness and vomits , it has been attempted to contact Dr. Rodriguez , unsuccessfully though. In spite of having being paged once and again, as from Veronica’s admission to the Hospital till her demise, Dr.Rodriguez has been all the time unavailable and out of reach or else he has always been late. Not only has he always been late or absent but also he has not even dared to enter any entry in the medical records and clearly enough , he had left the case in the hands of the registered nurses without even giving a diagnosis .


7. As Dr. Rodriguez was out of reach, an obstetrician Dr.Li had to be called in emergency and ordered to have medical tests done , a liquid diet (???) and a vial of Demerol (derived from morphine) which was absolutely useless for this is used to calm but not to find out the real cause of such pain. It is important to point out , that the idea was not to calm genital pains caused by labor but the epigastrics, whose cause remained without any explanation. (page 9)


8. Also, in the medical record you can read an entry saying “Respiratory stand by’s intro ven x 45’ ” which is very confusing . There is no reference made to the real status of the patient , her medical condition or time of the entry. Worse though is that there is an electrocardiogram covering the page hindering whatever important or not had been written below.(page 10)


9. The only real fact is that controls had been few and isolated and in spite of the alarming signals, the medical staff remained unconcerned. Besides, after 14:30 till 18:00 there is a total absence of entries in the medical history. Although is truth that in the separate pages you can find entries of the Code Blue but there is no chronological sequence in it. So, in a page you find entries about what happened at 18:00 and in the next page, strangely enough, you find entries with the diagnosis and treatment given at 17.45: Eclampsy. Haematuria. Hyperreflexia. Maintain magnesium sulfate. Sodium bicarbonate . (page 11)


10. Patient Progress Records states at 18:00 - Admitted into maternity , accompanied by the doctor. +RN – slight hypertension - lungs condition was stable - Respiratory Assistance (RA) – Haematuria . (page 10)


11. When was Respiratory Assistance administered? In the succinct CODE BLUE pages the equipment was required at 16:30 and it came at 16:33. It is also stated that the patient went into convulsions and was completely unconscious. Various tensional levels are registered (the first being particularly abnormal: 146/ 99,22 mm Hg) Determination of arterial blood gas is requested by the doctors .The report says AERIAL TRACT IS ORAL…. What does this phrase mean? Aerial tract is always oral and incidentally nasal or by tracheotomy. Why then it has not been acknowledged that beyond doubts she needed to be intubated or managed with an ambu, to get RA? (page 12-13)


12. What for and where was she administered local anesthesia? (Dermoplast-Benzocaine)The patient didn’t have pelvic pain and even if this had been the case , local anesthesia would have not eased the pain. Usually, these type of anesthetics are used to anesthetize the oral part of pharynx so as to insert a nasogastric tube or a tube for endotracheal intubation . So why she was administered local anesthesia on June 30th. at 11:40 hs?(page 14)


13. Regarding respiration, in the CODE BLUE sheet , as aforementioned, the only reference made is that the aerial tract WAS ORAL. In addition you can read that the oxygen saturation ,when the team arrived ,was of 92% and that there was a wheezing in the superior aerial tract. Under the item intubation, you have no entries. However, the pressure of arterial blood gas was of 150 mm Hg at 16:49. How did she reach that value when arterial blood gas on room air is 100 mm Hg? How is it that she has to go intubated to IUC when in the CODE BLUE sheets there is no reference to such a situation? The only description therein made was AERIAL TRACT IS ORAL…(page 12)


14. Poor and almost sporadic information is shown in the prenatal flow sheets on June 30th. Before labor blood pressure entries are at 03:00; 04:00 , 05:00 and 06:00. The values shown there were all abnormal and even quite unbelievable, eg. Value change from 151/91 mmHg goes to 142/55 without any medical intake in the middle. Also, after labor checkups were made during 2 hours each 15 minutes, but as above mentioned after 08:00 the next entry was only made at 09:00 with a value of 140/56 and the next one at 12:00 yielding an alarming value ( 170/55 mm Hg) that should have caused alarm and consequently, the immediate staff intervention.


15. Unfortunately , if we consider the Progress Record , such medical staff didn’t exist since there is no record on the medical history till the doctor for emergencies , Dr. Lee , intervened and without registering the timetable of his intervention , he prescribed analysis and anodyne measures , such as a liquid diet.!


16. Apparently the registered nurses are the ones to be blamed for they were not conscious of their role which was, supposedly, to replace the doctors and therefore the checkups had been scarce and they failed to give the symptoms the importance they have . On June 30th. at 11:00, 12:00 and 14:00 they registered in the maternal flow sheets ABDOMINAL PAIN - ACHING GRADES 6, 5 and 8. No reference has been made that this symptom had been informed to the doctors in charge, which as aforementioned , has nothing to do with the normal consequences of labor. On the contrary , this symptom is a clear alert of eclampsy and most of all of H.E.L.L.P.syndrome.


17. Moreover, in the same maternal flow sheets , same time as before mentioned you can read “Behavior : Agitated” . Once again the nurses were not alarmed by this. Six hours have passed by after labor , the parturient was still being agitated but there was nothing to be worried about.


18. Poor information, lack of clarity in the registers most of them illegible which is a serious fault since if a doctor was called in emergency , how could he get an idea of what the patient previous medical scenario was?; All these have been a constant in the medical history. In fact, the medical history is full of abbreviations or acronyms almost unknown for the common of the doctors. To picture this, in the progress record on June 30th. at 17:15 you can barely read : “Code Blue Note: Code Blue Note called 2º to pt. Because unresponsive eyes rolli … foamy secretions … “ (the rest of it is illegible)(page 15)

19. The issue of the platelets remains particularly unclear to any fairly educated doctor . We all know that the normal number of this cells in peripheral blood is of 150.000 to 400.000 mm3 . In Veronica’s case, the register at 04:35 showed 222.000mm3 and strangely , another blood test was ordered at 16:05, showing 119.000mm3 . This last test should have raised alarm since in all studies, treatises or papers made on the subject, it is very clear that platelets below 150.000 m3 shall cause great concern . Why? Because proteinuria and the increase of the levels of uric acid are useful to diagnose preeclampsy but not to detect H.E.L.L.P. syndrome. The best indicator to detect H.E.L.L.P. syndrome is the number of platelets. Doctors and nurses of Huntington Memorial Hospital had seen that result but haven’t done anything . It was exactly at that moment that H.E.L.L.P. syndrome should have been diagnosed. Accordingly a vigorous line of action should have been carried out so as to control blood pressure and to substitute by means of blood transfusions the platelets that were in decrease. It is obvious that an early diagnosis was critical for effective treatment of such syndrome.(page 16)


20. However, long before there had been a tests whose abnormal results should have been reason enough to be taken as a warning. At 04:35 fibrin degradation products (pdf) which should be lower than 5, showed a level higher than five but lower than twenty. This result that forced to discard the onset of a consumption coagulopathy has not been object of concern to the health professionals involved. In fact, they should have ordered a D-Dimer test, which is a sensitive indicator of a sub-clinical coagulopathy and it can be positive before that coagulation tests show abnormalities. However, this hasn’t been done. The subsequent progress of the patient reports coagulopathy : at 18:15 pdf was higher than twenty , fibrin diminished to 113 mg % ( reference level: 200 to 400); as for the platelets they diminished much more. (page 17)


C) FINAL DIAGNOSIS :

1. None of the involved obstetricians , Dr. Lee or Dr. Rodriguez, have registered a specific diagnosis in the clinical history till it was too late. Moreover, their almost inexistent and poor remarks are superficial and incidental. They’ve not made any reference to hypertension, proteinurea, thrombocytopenia, etc. They treated abdominal pain as a regular puerperal pain by administering Vicodin and Demerol or as it would have been a gastritis they administered Mylanta. They have never been conscious of the existence of a preeclampsy , eclampsy or H.E.L.L.P. syndrome. Only at 17:15 (page 15)they wrote :” Pt is in eclampsia (pt has elevated BP during peripartum period” . Then , at 05,15 on July 1st. when the patient did not respond to verbal orders or pain stimulus, that is to say , when she was beyond hope , gone for ever, Rodriguez wrote: “ Lab: as noted: Hellp syndrome”.


2. Dr. Gurevich (page 18)has been the first one to wonder about the possibility of “preeclamsy during pregnancy “, at 19:00 , once the symptoms were completely displayed and as an unidentified subject established that Veronica was already in an eclampsic condition (page 11).However, although he had suspected a preeclampsy and he was witnessing the first eclampsy consequences such as convultions, even though the patient had upper abdominal pain, and in spite of her having a low quantity of platelets , he has not concluded a H.E.L.L.P. syndrome diagnosis , neither did he indicated platelets transfusions to the patient nor any other effective action in order to stop the coagulopathy.

3. The Hospital ‘s final diagnosis written in the Attestation Report has been the followingpage 19)

Principle Diagnosis: Cord entangle neck

Secondary diagnosis :
674.02 – Cerebrovascular disease
666.32 – Coagulation deficiency
642.52 – Severe preeclampsia

The above categorization of the diagnosis is incoherent : If Cord entangle neck is considered as the principle diagnosis just because it has been the first one , that could work but if we consider this as the main diagnosis it is absurd.
The cordon around the neck might harm the newborn baby but not the mother.

She died because she suffered bassicaly a preclampsia undetected by RN and doctors of Huntington Memorial.Hospital.With any kind of managing or accurate treatement,preeclampsia progressed to severe eclampsia which developed in a HELLP syndrome with a drastic drop of platelets and intravascular consumption of fibrinogen which led to an intracerebral hemorrhage ,killing Veronica.

4. In the Discharge Summary ,(page 20) Dr. Rodriguez describes the evolution of the medical symptoms of the patient without mentioning eclampsy diagnosis or H.E.L.L.P. syndrome in it. As discharge diagnosis he establishes the following: “Disease due to cardiorrespiratory failure due to brain hemorrhage. However, cardiorrespiratory failure is the final form of death of all individuals and brain hemorrhage might respond to many causes: brain injury, artery aneurysm rupture, arteriovenous malformation, hypertensive crise, encephalic tumor, coagulopathies, etc. In short, the Discharge Summary failed to provide a specific diagnosis ( It`s obvious that Rodriguez made a false statement to hide the true fact of his enormous lack of knowledge and gross negligence)


5. Finally, there is another surprisingly fact. No one from Los Angeles County Department of Coroner has reviewed the medical history. However, in the entry To Report a Death you can read that this death was not a coroner case per LA Coroner Office. Apparently , the communication was made through Internet because at the superior angle of the page you can read : “ Dr. Lois Pena @ L.A. coroner Office declines as coroner case”.(page 21)


CONCLUSIONS:

1. Veronica was a healthy young woman
2. She was intelligent and blessed with great artistic sensibility
3. However, she -as any other human being- could have passed away for many reasons: a road accident, an infection or as a result of unpredictable complications during pregnancy such as an hemorrhage due to placenta previa , an endovascular coagulopathy due a detached placenta, etc.
4. But, she was treated by doctors and registered nurses whose gross negligence and clear lack of skill led my daughter to her death:

a. They didn’t notice that the patient was having clear signs of preeclampsy during the pregnancy


b. The abnormally high tensional registers taken from the very beginning when she had been admitted into hospital have not caused any concern to the doctors neither have they given rise to communications of any kind among them.
c. After labor the levels of blood pressure during the first two hours have been abnormal. However, there is no proof that this situation has been informed to the doctors and therefore, controls more often . After the first two hours controls and entries are scarce and more isolated.


d. Epigastric pain, nausea and vomits are symptoms that should have given raise to great concern. Mostly since the frequency of such symptoms are clear indicators of H.E.L.L.P. syndrome . However, they have been minimized, attributed to gastritis and ridiculously treated with a diet, Mylanta, etc.


e. The indication to administer Vicodin or Demerol (narcotics agents) to trat an epigastric pain is also an obvious and blatant example of the lack of medical skill.


f. The fact that the medical staff has not taken immediate action when an sudden drop of platelets has taken place, which in fact could not have been attributed to nothing but intravascular coagulation which is the most important sign of H.E.L.L.P. syndrome , is another proof of their lack of skill.

GREGGORY R .DEVORE MD,FAILED TO DIAGNOSE-AN ARTICLE ABOUT WRONG DIAGNOSIS

Greggory r Devore,MD ,is a renowned ultrasound specialized doctor with offices in Pasadena California.He signed the attached report .He states there that there´s no concerns about IUGR or toxemia which was clearly visible on the ecosound as experts pointed out.
I visited him at his office and during two long hours tried to explain that...well the baby was little,bla bla bla..............Indiana agote Glaubach,my granddaughter weighed 2,090 at the time when he was born.That weight is a clear signal of IUGR(Intra Uterin Grow Retardement),abnormal weight and it is showed in the ecosound..with brights in placenta.I´m sure that he never saw the ecosound which maybe has been signed by his assistant or mayby by his secretary. Liar and wrongdoer indeed !!The Wrong Diagnosis
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Read More: Andrew Weil, Dr. Andrew Weil, Health, Health Bill, Health Care, Health Care Bill, Health Reform, Obama Health Care, Living News

So let´s see some concepts about WRONG DIAGNOSIS
(no treatment as a logical consequence)

The Wrong Diagnosis
digg stumble reddit del.ico.us ShareThis
Read More: Andrew Weil, Dr. Andrew Weil, Health, Health Bill, Health Care, Health Care Bill, Health Reform, Obama Health Care, Living News


I'm worried -- and if I'm worried, you should be, too.

The reason I'm worried is that the wrong diagnosis is being made.

As any doctor can tell you, the most crucial step toward healing is having the right diagnosis. If the disease is precisely identified, a good resolution is far more likely. Conversely, a bad diagnosis usually means a bad outcome, no matter how skilled the physician.

And, what's true in personal health care is just as true in national health care reform: Healing begins with the correct diagnosis of the problem.

Washington is working on reform initiatives that focus on one problem: the fact that the system is too expensive (and consequently too exclusive.) Reform proposals, such as the "public option" for government insurance or calls for drug makers to drop prices, are aimed mostly at boosting affordability and access. Make it cheap enough, the thinking goes, and the 46 million Americans who can't afford coverage will finally get their fair share.

But what's missing, tragically, is a diagnosis of the real, far more fundamental problem, which is that what's even worse than its stratospheric cost is the fact that American health care doesn't fulfill its prime directive -- it does not help people become or stay healthy. It's not a health care system at all; it's a disease management system, and making the current system cheaper and more accessible will just spread the dysfunction more broadly.
It's impossible to make our drug-intensive, technology-centric, and corrupt system affordable. Consider that Americans spent $8.4 billion on medicine in 1950, vs. an astonishing 2.3 trillion in 2007. That's $30,000 annually for a family of four. The bloated structure of endless, marginal-return tests; patent-protected drugs and "heroic" surgical interventions for virtually every health problem simply can't be made much cheaper due to its very nature. Costs can only be shifted in various unpalatable ways.

So, a far more salient question that must be addressed is: Are we getting good health for our trillions? Unfortunately, the answer is a resounding, "No." The U.S. ranked near the very bottom of the top 40 nations -- below Columbia, Chile, Costa Rica and Dominica -- in a rating of health systems by the World Health Organization in 2000. In short, we pay about twice as much per capita for our health care as does the rest of the developed world, and we have almost nothing to show for it.

I'm not against high-tech medicine. It has a secure place in the diagnosis and treatment of serious disease. But our health care professionals are currently using it for everything, and the cost is going to break us.

In the future, this kind of medicine must be limited to those cases in which it is clearly indicated: trauma, acute and critical conditions, disease involving vital organs, etc. It should be viewed as a specialized form of medicine, perhaps offered only in major centers serving large populations.

Most cases of disease should be managed in other, more affordable ways. Functional, cost-effective health care must be based on a new kind of medicine that relies on the human organism's innate capacity for self-regulation and healing. It would use inexpensive, low-tech interventions for the management of the commonest forms of disease. It would be a system that puts the health back into health care. And it would also happen to be far less expensive than what we have now.

If we can make the correct diagnosis, the healing can begin. If we can't, both our personal health and our economy are doomed.

Politicians aren't going to resolve this issue overnight. Any health care reform bill that gets jammed through Congress in the next month or two will be dangerously flawed. Washington needs to take a step back and re-examine the entire task with an eye toward achieving the most effective solution, not the cheapest and most expeditious.


Ecosound done by Dr Gregory Devore,Pasadena showing in a clear cut "brights in the placenta" a blatant sign of preclampsia..NOBODY TOOK A LOOK ON THIS


Greggory Devore,MD ,is a renowned ultrasound specialized doctor with offices in Pasadena California.He signed the attached report .He states there that there´s no concerns about IUGR or toxemia which was clearly visible on the ecosound as experts pointed out.
I visited him at his office and during two long hours tried to explain that...well the baby was little,bla bla bla..............Indiana agote Glaubach,my granddaughter weighed 2,090 at the time when he was born.That weight is a clear signal of IUGR(Intra Uterin Grow Retardement),abnormal weight and it is showed in the ecosound..with brights in placenta.I´m sure that he never saw the ecosound which maybe has been signed by his assistant or mayby by his secretary. Liar and wrongdoer indeed !!The Wrong Diagnosis
digg stumble reddit del.ico.us ShareThis
Read More: Andrew Weil, Dr. Andrew Weil, Health, Health Bill, Health Care, Health Care Bill, Health Reform, Obama Health Care, Living News

So let´s see some concepts about WRONG DIAGNOSIS
(no treatment as a logical consequence)

The Wrong Diagnosis
digg stumble reddit del.ico.us ShareThis
Read More: Andrew Weil, Dr. Andrew Weil, Health, Health Bill, Health Care, Health Care Bill, Health Reform, Obama Health Care, Living News


I'm worried -- and if I'm worried, you should be, too.

The reason I'm worried is that the wrong diagnosis is being made.

As any doctor can tell you, the most crucial step toward healing is having the right diagnosis. If the disease is precisely identified, a good resolution is far more likely. Conversely, a bad diagnosis usually means a bad outcome, no matter how skilled the physician.

And, what's true in personal health care is just as true in national health care reform: Healing begins with the correct diagnosis of the problem.

Washington is working on reform initiatives that focus on one problem: the fact that the system is too expensive (and consequently too exclusive.) Reform proposals, such as the "public option" for government insurance or calls for drug makers to drop prices, are aimed mostly at boosting affordability and access. Make it cheap enough, the thinking goes, and the 46 million Americans who can't afford coverage will finally get their fair share.

But what's missing, tragically, is a diagnosis of the real, far more fundamental problem, which is that what's even worse than its stratospheric cost is the fact that American health care doesn't fulfill its prime directive -- it does not help people become or stay healthy. It's not a health care system at all; it's a disease management system, and making the current system cheaper and more accessible will just spread the dysfunction more broadly.
It's impossible to make our drug-intensive, technology-centric, and corrupt system affordable. Consider that Americans spent $8.4 billion on medicine in 1950, vs. an astonishing 2.3 trillion in 2007. That's $30,000 annually for a family of four. The bloated structure of endless, marginal-return tests; patent-protected drugs and "heroic" surgical interventions for virtually every health problem simply can't be made much cheaper due to its very nature. Costs can only be shifted in various unpalatable ways.

So, a far more salient question that must be addressed is: Are we getting good health for our trillions? Unfortunately, the answer is a resounding, "No." The U.S. ranked near the very bottom of the top 40 nations -- below Columbia, Chile, Costa Rica and Dominica -- in a rating of health systems by the World Health Organization in 2000. In short, we pay about twice as much per capita for our health care as does the rest of the developed world, and we have almost nothing to show for it.

I'm not against high-tech medicine. It has a secure place in the diagnosis and treatment of serious disease. But our health care professionals are currently using it for everything, and the cost is going to break us.

In the future, this kind of medicine must be limited to those cases in which it is clearly indicated: trauma, acute and critical conditions, disease involving vital organs, etc. It should be viewed as a specialized form of medicine, perhaps offered only in major centers serving large populations.

Most cases of disease should be managed in other, more affordable ways. Functional, cost-effective health care must be based on a new kind of medicine that relies on the human organism's innate capacity for self-regulation and healing. It would use inexpensive, low-tech interventions for the management of the commonest forms of disease. It would be a system that puts the health back into health care. And it would also happen to be far less expensive than what we have now.

If we can make the correct diagnosis, the healing can begin. If we can't, both our personal health and our economy are doomed.

Politicians aren't going to resolve this issue overnight. Any health care reform bill that gets jammed through Congress in the next month or two will be dangerously flawed. Washington needs to take a step back and re-examine the entire task with an eye toward achieving the most effective solution, not the cheapest and most expeditious.


viernes, 13 de noviembre de 2009

Geronimo Rodriguez Md ,Joseph Y Li ,Michael Gurevitch and pseudo experts of the RNB and MBC take a look over this article and try, to learn.PLEASE!!

Aggressive Management of Hellp Syndrome and Eclampsia
Judith H. Poole, RNC, MN, FACCE
Hypertensive disorders are the most common medical complication of pregnancy.1,2 A significant contributor to maternal and perinatal morbidity and mortality,3,4 hypertension is estimated to complicate approximately 7% to 10% of all pregnancies.5 In the United States, preeclampsia ranks second only to embolic events as a major cause of maternal mortality and is directly responsible for approximately 18% of maternal deaths.3 Eclampsia is responsible for approximately 50,000 maternal deaths worldwide each year.6 The prevalence of pregnancy-related hypertension has not varied markedly since 1989, when data for this medical risk factor were first available from vital statistics.7

Pregnancy-induced hypertension (PIH) is a subtle and insidious disease process. The signs and symptoms of PIH become apparent relatively late in the course of the disease, usually during the third trimester of pregnancy. However, the underlying pathophysiology may be present as early as the eighth week of gestation.8,9 This delay between the clinical manifestation of signs and symptoms and the onset of the hypertensive pathology can place the woman and fetus at increased risk for nonoptimal outcomes before the care provider is aware of a problem. Therefore, the health care provider must be aware of subtle changes that may be indicative of impending disease.

Historically, several well-defined risk factors have been identified for the development of PIH (Table 1).10,11 Although risk factors are identified, the individual predictive value of the risk factors for screening and for risk identification has not been verified.

Classification of Disease
Terminology used to describe the hypertensive disorders of pregnancy is imprecise, causing confusion for the provider caring for women with hypertensive complications during pregnancy and childbirth. The American College of Obstetricians and Gynecologists' (ACOG) technical bulletin no. 219, Management of Preeclampsia, outlines the current accepted terminology for the hypertensive disorders of pregnancy.5

Two basic types of hypertension occur during pregnancy: chronic hypertension and pregnancy-induced hypertension. The difference is the time of onset in relation to the pregnancy. Chronic hypertension is that which predates the pregnancy or continues beyond 42 days postpartum. Pregnancy-induced hypertension, with onset generally after the 20th week of pregnancy, is a marker for a pregnancy-specific vasospastic condition. Clinically, chronic hypertension and PIH may coexist or occur as separate disease processes.5

Once PIH is recognized, it is further classified according to the maternal organ systems affected. Preeclampsia is the progression of PIH, characterized by renal pathology as evidenced by the onset of proteinuria. Pre-eclampsia is either mild or severe, based on maternal or fetal clinical findings. The HELLP syndrome, a form of severe preeclampsia, is a laboratory diagnosis characterized by hepatic pathology as evidenced by hemolysis (H), elevated liver enzymes (EL), and low platelets (LP). Eclampsia is the onset of seizure activity in the woman diagnosed with PIH who has no history of a neurologic or metabolic derangement.5


Table 1. Risk Factors for Pregnancy-Induced Hypertension

· First pregnancy or pregnancy of new genetic make-up

· Multifetal gestation

· The presence of preexisting diabetes, collagen vascular disease, hypertension, or renal disease

· Hydatidiform mole

· Fetal hydrops

· Maternal age (<18 y or >35y)

· Maternal weight (<100 lbs or obese)

· African-American race

· Family history of pregnancy-induced hypertension

· Antiphospolipid syndrome

· Low socioeconomic status

· Late entry or no prenatal care


Pathophysiology of Preeclampsia
Preeclampsia has been called the "disease of theories." There is no single agreed-upon etiology, but ongoing research is attempting to identify the pathophysiology of this process. Although the exact mechanism is unknown, preeclampsia is thought to occur secondary to alterations of the normal physiologic adaptations of pregnancy. Arterial vasospasm, endothelial damage, and platelet aggregation with resultant tissue hypoxia are underlying mechanisms for the clinical manifestation of preeclampsia. In Table 2, the normal hemodynamic values of pregnancy are shown.

Table 2. Normal Hemodynamic Values for Pregnancy



Easterling et al.12,13 propose that preeclampsia is a hyperdynamic condition, in which the characteristic findings of hypertension and proteinuria result from an increase in cardiac output above normal pregnancy values and renal hyperperfusion. To control the hyperperfusion, renal vasospasms are initiated as a protective mechanism, but the vasospasms eventually produce endothelial damage, proteinuria, and hypertension characteristic of preeclampsia. In several other studies, investigators have proposed that preeclampsia results from endothelial cell injury; increased platelet activation, with platelet consumption in the microvasculature; and excessive clotting activity.8,14-16 In addition to endothelial damage, arterial vasospasm may contribute to the increase in capillary permeability and red blood cell (RBC) destruction. Endothelial damage and increased capillary permeability allow for increased edema and further depletion of intravascular volume and reduction in colloid osmotic pressure.

The destruction of red blood cells is of concern in women with severe preeclampsia. In the report of a recent study, it is suggested that severe preeclampsia is a state of fixed oxygen extraction.17 Women with severe preeclampsia demonstrate an abnormally low oxygen consumption, even at high oxygen-delivery levelsùa finding that may prove clinically significant. With a tissue-level oxygen extraction defect, the maternal end-organs and the utero-placental-fetal units will not be adequately perfused.

The most common coagulation abnormality seen in preeclampsia is platelet consumption that results in thrombocytopenia. Arterial vasospasms damage the endothelial lining of blood vessels, activating the hemostatic system and causing platelet aggregation and the formation of a fibrin network.18,19 Platelet aggregation reduces available circulating platelets and causes a narrowing of the vessel lumen. As RBCs are forced through the fibrin network under high pressure, hemolysis occurs.18,19

As preeclampsia worsens, renal involvement leads to changes in urinary output and in serum chemistries. Renal blood flow and glomerular filtration are decreased, resulting in oliguria, decreased urine creatinine clearance, and increased blood urea nitrogen, serum creatinine, and serum uric acid.20

Preeclampsia affects the central nervous system (CNS) by inducing cerebral edema and increased cerebral resistance.20 Complications may include headaches, seizures, or cerebral vascular accidents. As CNS involvement worsens, the patient will complain of headaches and visual disturbances or exhibit changes in mentation and level of consciousness. A life-threatening complication of preeclampsia is the development of eclampsia.

The CNS effects of preeclampsia may be responsible for an increase in systemic vascular resistance and hypertension. Recent research suggests that preeclampsia is a state of sympathetic overactivity21 that causes an increase in sympathetic-mediated vasoconstrictor activity.

Clinical Manifestations of Preeclampsia
Historically, the classic triad of symptoms for preeclampsia includes hypertension, proteinuria, and edema. However, all of these parameters need not be present for a diagnosis of preeclampsia. (Hypertension alone is diagnosed as PIH.) Hypertension and proteinuria are the most significant indicators of preeclampsia. Edema is significant only if hypertension, proteinuria, or signs of multisystem organ involvement are present. The clinical manifestations of preeclampsia are directly related to the presence of vascular vasospasms. These vasospasms result in endothelial injury, RBC destruction, platelet aggregation, increased capillary permeability, and increased systemic vascular resistance, leading to tissue hypoxia and multiorgan system dysfunction.

Hypertension
Although controversy exists about the most appropriate definition of hypertension, current ACOG5 criteria define hypertension as a sustained blood pressure elevation of 140/90 mmHg after the 20th week of gestation, as recorded on two or more measurements taken at least 6 hours apart. An elevation of 30 mmHg in systolic or 15 mmHg in diastolic pressure above first trimester or prepregnancy baseline values is of questionable use for defining hypertension during pregnancy. MacGillivary et al.22 reported that 73% of nulliparous women with normal pregnancy outcomes demonstrated an increase in diastolic blood pressure of more than 15 mmHg during pregnancy, whereas 57% of these women demonstrated an increase in diastolic pressure of more than 20 mmHg. Results of later studies have confirmed these findings.22-24

Proteinuria
Proteinuria is the excretion of 0.1 g/L (100 mg/L) protein in a random urine specimen, or 0.3 g/L in a 24-hour specimen (300 mg/L), or 1 to 2+ on dipstick. The presence of proteinuria indicates a worsening of the disease process increasing the risk to the woman and the fetus.25,26

In a recent study, the accuracy of routine dipstick analysis to diagnose proteinuria in hypertensive patients is questioned. Meyer et al.27 reported that among negative or trace readings on urinary protein dipstick determinations, clinically significant proteinuria of 300 mg or more per 24 hours was confirmed by 24-hour urine collections. Furthermore, the negative predictive value for urinary protein dipstick determinations was stated to be 34%. Based on the results reported by Meyer27 asymptomatic women with early renal changes consistent with preeclampsia may be inappropriately diagnosed as disease free.

Edema
Edema is a common finding of pregnancy and is not necessary for the diagnosis of preeclampsia. Intracellular and extracellular edema is present, representing a generalized and excessive accumulation of fluid in tissue. As vasospasms worsen, capillary endothelial damage increases systemic capillary permeability (leakage), leading to hemoconcentration and an increased risk of pulmonary edema.

Severe Preeclampsia
To identify the progression of preeclampsia from mild to severe disease, nursing management requires accurate and thorough observation and assessments. Criteria for severe preeclampsia are in Table 3, and the potential maternal and fetal complications of severe preeclampsia are in Table 4. Table 5 shows laboratory values typical in women with severe preeclampsia or the HELLP syndrome. Severe preeclampsia and the HELLP syndrome are multiorgan system disease processes. The wide range of symptoms and multiple organ system involvement can result in misdiagnosis or delay in treatment. Cocaine intoxication, lupus nephritis, chronic renal failure, and acute fatty liver of pregnancy are examples of conditions that may mimic preeclampsia and eclampsia.28-32

HELLP Syndrome
HELLP syndrome19,33, a multisystem disease, is a form of severe preeclampsia in which the woman reports a variety of complaints and exhibits common laboratory markers for a syndrome of hemolysis (H), elevated liver enzymes (EL), and low platelets (LP). This subset of women progress from preeclampsia to the development of multiple organ system compromise. The complaints range from malaise, epigastric pain, and nausea and vomiting to nonspecific viral syndrome-like symptoms. Symptoms generally develop in these patients in the second or early third trimester of pregnancy; initially, they may show few signs of preeclampsia. Because of the symptomatology these patients often receive a nonobstetric diagnosis, delaying treatment and increasing maternal and perinatal morbidity and mortality.18,19,33,34 Assessments and management of the woman diagnosed with HELLP syndrome are the same as for the woman with severe preeclampsia.


Table 3. Criteria for Severe Preeclampsia

· Systolic blood pressure of 160 mmHg or diastolic blood pressure of 110 mmHg on two occasions at least 6 hours apart with the patient on bedrest

· Proteinuria of 5 g or greater in 24 hours, or 3-4+ on dipstick

· Oliguria, less than 400-500 mL of urine output over 24 hours, or altered renal function tests

· Elevated serum creatinine > 1.0 mg/dL

· Intrauterine growth restriction

· Cerebral or visual disturbances including but not limited to altered level of consciousness, headache, scotomata, or blurred vision

· Impaired liver function demonstrated by right upper quadrant or epigastric pain and/or altered liver function

· Thrombocytopenia: platelet count < 150,000

· Pulmonary or cardiac involvement: may present as pulmonary edema, cyanosis, chest pain, cardiac dysrhythmias




Table 4. Potential Maternal and Fetal Complications of Severe Preeclampsia

· Cardiovascular: severe hypertension, hypertensive crisis, pulmonary edema

· Renal: oliguria, acute renal failure

· Hematologic: hemolysis, decreased oxygen-carrying capacity, thrombocytopenia, coagulation defects including disseminated intravascular coagulation

· Neurologic: eclampsia, cerebral edema, cerebral hemorrhage, cerebral vascular accidents, amaurosis (blindness)

· Hepatic: hepatocellular dysfunction, hepatic rupture, hypoglycemia

· Uteroplacental: abruptio placentae, fetal growth retardation, fetal intolerance to labor, fetal death




Table 5. Laboratory Findings With Severe Preeclampsia and the HELLP Syndrome



Eclampsia
Eclampsia is the development of convulsions, coma, or both in a woman with signs and symptoms of preeclampsia. Other causes of seizures must be excluded. Eclampsia can occur antepartum, intrapartum, or postpartum; approximately 50% of cases occur antepartum.35

The immediate care during a convulsion is to ensure a patent airway. Once this has been attained, adequate oxygenation must be maintained by use of supplemental oxygen. MgSO4 (and amobarbital sodium for recurrent convulsions) is given according to institution protocol.5,36 Suggested management of an eclamptic seizure is as follows:2,36

· Do not attempt to shorten or abolish the initial convulsion. Attempts to administer anticonvulsants intravenously without secure venous access can lead to phlebitis and venous thrombosis.

· Prevent maternal injury during the convulsion. Because the woman may have vomiting, the airway must be protected.

· Maintain adequate oxygenation. Once the convulsion has stopped and the woman has begun spontaneous respirations, oxygenation status is monitored. If spontaneous respirations are not present, ventilatory support will be required.

· Minimize the risk of aspiration. The woman should be positioned to facilitate drainage from the mouth. Suction equipment should be readily available and in working order. Also, if supplemental oxygen is being administered by face mask, be aware of the possibility of vomiting and aspiration. After a convulsion, a chest radiograph may be ordered to rule out aspiration.

· Give adequate magnesium sulfate to control the convulsion. As soon as possible after the convulsion venous access should be secured and a 4- to 6-g loading dose of MgSO4 given in a 15- to 20-minute period. If the woman convulses after the loading dose, another 2-g bolus may be given intravenously, in 3 to 5 minutes.

· Correct maternal acidemia. Blood gas analysis will allow monitoring of oxygenation and pH status. Respiratory acidemia is possible after convulsion, but sodium bicarbonate is not administered unless the pH is less than 7.10.2 Ensuring adequate respiratory status is essential.

· Avoid polypharmacy. Maternal respiratory depression, respiratory arrest, or cardiopulmonary arrest is more likely in women receiving polytherapy to arrest convulsion. Remember that anticonvulsant drugs are respiratory depressants and may interact.


Rapid assessments of uterine activity, cervical status, and fetal status are performed. During the convulsion, membranes may rupture and the cervix may dilate because the uterus becomes hypercontractile and hypertonic. If birth is not imminent the timing and route of delivery (induction of labor versus cesarean delivery) depend on maternal and fetal status. All medications and therapy are merely temporary measures.

Medical Management for Severe Preeclampsia: The HELLP Syndrome
The only definitive therapy for preeclampsia is delivery. Objectives of medical management for any pregnancy complicated by severe preeclampsia or the HELLP syndrome are termination of pregnancy with the least possible trauma to mother and fetus, birth of an infant who subsequently thrives, and complete restoration of health to the mother.37 For the woman with mild disease, these objectives are reasonable.

For the woman with severe preeclampsia, HELLP syndrome or eclampsia, especially at preterm gestation, these objectives are often unrealistic. In this situation, delivery may be the most appropriate management decision. Suggested management for the woman with severe preeclampsia includes:36

· On diagnosis, admit to the hospital and initiate parenteral magnesium sulfate prophylaxis and antihypertensive therapy if diastolic blood pressure is higher than 110 mmHg for maternal pharmacologic management of severe preeclampsia-HELLP syndrome is described in Table 6.

· If there is evidence of maternal or fetal jeopardy, if gestational age is more than 34 weeks, or if labor has begun, deliver.

· If hospital admission results in stabilization of the woman and if gestational age is more than 28 weeks, consider expectant management; timing and route of delivery depend on evaluation of maternal or fetal assessments for reassuring findings and gestational age.

· If gestational age is 24 to 28 weeks, begin maternal counseling, institute prophylactic magnesium sulfate therapy and antihypertensive therapy as indicated, and monitor maternal and fetal status daily. Deliver if there is evidence of fetal lung maturity and maternal or fetal deterioration.

· If gestational age is less than 24 weeks, consider termination of pregnancy.


Additional management decisions include assessment of maternal central hemodynamic status and the treatment of persistent oliguria. Routine use of a pulmonary artery (PA) catheter in uncomplicated, severe preeclampsia is not recommended. Use of a PA catheter may be indicated if there are complications related to central volume status, including pulmonary edema, persistent oliguria unresponsive to traditional management, or intractable severe hypertension unresponsive to first-line antihypertensive agents.38,39

Management of persistent oliguria is based on the understanding that three hemodynamic subsets of preeclamptic eclamptic patients have been identified.40,41

· Hypovolemic oliguria is the most common clinical occurrence. Symptoms include low pulmonary capillary wedge pressure, hyperdynamic left ventricular function, and mild to moderate increased systemic vascular resistance. The condition is thought to be secondary to intravascular volume depletion and generally responds to fluid volume replacement.

· In renal artery spasm, normal or increased pulmonary capillary wedge pressure, normal cardiac output, normal systemic vascular resistance, and uroconcentration. Oliguria is thought to be secondary to intrinsic renal arterial spasm out of proportion to systemic vasospasm. Low-dose dopamine infusion (1- to 5-mg/kg per minute) may be used.

· Hypervolemic oliguria causes symptoms of elevated pulmonary capillary wedge pressure and systemic vascular resistance, with depressed ventricular function. Incipient pulmonary edema may be the first sign in this subset of patients with oliguria. Aggressive afterload reduction and diuresis should be used.


If urinary output is less than 25 mL/hour for 2 consecutive hours, a medical plan of care should be established. A fluid challenge of 500 to 1,000 mL of normal saline or lactated Ringer's solution is usually ordered to be infused in a 30-minute period. If urine output does not respond, and if the woman is not expected to deliver in a reasonable time, a PA catheter should be considered if more aggressive medical management is attempted.39,40


Table 6. Pharmacological Management of Severe Preeclampsia/HELLP Syndrome




Controversial Management Protocols
Several management protocols are considered to be inappropriate or controversial in the care of the woman with severe preeclampsia or eclampsia. Diuretics and the administration of high concentrations of colloid solutions (albumin, hetastarch) should not be used to decrease peripheral edema caused by further depletion of intravascular volume and an increased risk of pulmonary edema and uteroplacental insufficiency.20,42 Valium is no longer the first-line agent to stop seizure activity related to the depressant effect on the fetus and mother.2 If diazepam is ordered, a rapid bolus may lead to apnea, cardiac arrest, or both. Diazepam should not be administered intravenously unless someone skilled in intubation is immediately available.2 Seizure precautions, including administration of intravenous magnesium sulfate, should be followed according to institution protocol. Finally, heparin should not be administered as prophylaxis against coagulopathy because of the compromise in the maternal vascular system.43

Nursing Implications
Nursing care involves very accurate and astute observations and assessments. A comprehensive knowledge base regarding pharmacologic therapies, management regimes, and possible complications is also required.

Assessments
Preeclampsia can occur without warning or with the gradual development of symptoms. Systematic assessments are critical, with the frequency of assessments dictated by the patient's (maternal or fetal) condition and response to therapy.

History. Obtain a thorough medical and perinatal history on all women diagnosed with PIH. The medical history includes the presence of underlying cardiovascular disease, diabetes, systemic lupus erythematosus, renal disease, pulmonary disease, migraine headaches, or seizure disorders. Perinatal history includes the presence of PIH, abruptio placentae, fetal demise, or fetal growth restriction in any previous pregnancy; also, include past pregnancy outcomes. Current pregnancy history includes prepregnancy blood pressure, presence of proteinuria, hypertension, amniotic fluid volume, fetal growth, fetal assessment test results, and current fetal status. It is also important to note whether the woman complains of unusual, frequent, or severe headaches, visual disturbances, or epigastric pain.

Cardiovascular Assessment. The cardiovascular assessment is performed to identify signs of cardiac decompensation. Assessments include the following parameters: auscultation of heart sounds, lungs, and breath sounds; edema, increases or changes every shift; early signs or symptoms of pulmonary edema, including tachycardia and tachypnea; daily weight; skin color, temperature, and turgor; capillary refill. Oxygen saturation monitoring (pulse oximetry) and cardiac monitoring are performed if indicated by clinical condition; however, neither should replace clinical assessment.

Accurate and consistent blood pressure assessment is important for establishing a baseline and for monitoring subtle changes throughout the pregnancy. Blood pressure readings are affected by maternal position and measurement techniques. Consistency in obtaining readings must be ensured, including proper equipment and cuff size, correct position of the woman, a rest period before recording the pressure, and use of Korotkoff phase IV sounds.44-47 Debate remains within the medical community regarding which Korotkoff sound (phase IV or V) should be used for evaluating diastolic blood pressure. Korotkoff sound phase IV is characterized by a muffling of the sound, whereas phase V is the disappearance of the sound. The World Health Organization (WHO), The British Hypertension Society, and the International Society for the Study of Hypertension in Pregnancy (ISSHP) all recommend that phase IV be used in recording diastolic blood pressure. Phase IV measurement is more reproducible during pregnancy, but when compared with intraarterial catheters, phase IV may overestimate diastolic pressures by as much as 15 mmHg.48,49 Phase V measurement can be more accurately determined than phase IV, but women demonstrate an extremely wide variation in phase V readings because of the hyperkinetic circulation of pregnancy.47 It is not unusual in pregnancy to obtain a phase V measurement of 0.

If the initial blood pressure measurement indicates an elevation, the woman should be allowed to relax and have a repeat measurement performed, maintaining position used for initial measurement.5 In using electronic blood pressure devices, there is a normal widening of the pulse pressure compared with that in manual readings; however, the mean arterial pressure is unchanged.50,51 The main point to remember is that blood pressure measurements should be taken in a consistent manner, because assessments focus on blood pressure trends that develop with passing time, not a single reading.

The presence of edema plus hypertension or proteinuria warrants additional investigation. Edema is assessed by distribution and degree. Assessments are directed at signs of cardiopulmonary and renal involvement, indicating worsening of disease.

Respiratory Assessment. Respiratory assessments are performed to identify signs of pulmonary edema, respiratory compromise, or magnesium toxicity. Respiratory rate is evaluated for rate, quality, and pattern, especially if receiving magnesium sulfate, to identify early signs of toxicity. Labored respirations or use of the accessory muscles are assessed. Breath sounds are auscultated every shift, or more often if indicated, to identify diminished breath sounds, crackles, or wheezes; pulmonary edema can develop very quickly. Tachypnea and tachycardia are early signs of evolving pulmonary edema. Skin color and mucous membranes are assessed for the presence of cyanosis, which may indicate problems with oxygenation or perfusion. Monitoring oxygenation status with pulse oximetry is performed as indicated by the woman's clinical condition and response to therapy. However, pulse oximetry should not replace clinical assessments.

Renal Assessment. Renal assessments are performed to identify signs of renal failure. The volume of urinary output is evaluated every 1 to 4 hours. The output should be at least 25 to 30 mL/hour or 100 mL/4-hour period. If oliguria is present (less than 25 mL/hour) or serum creatinine is elevated, the woman is at increased risk for magnesium toxicity. Urine is evaluated for protein by dipstick analysis. However, testing proteinuria by dipstick analysis may be a poor substitute for a 24-hour urine in women with preeclampsia or the HELLP syndrome.27 A 24-hour urine collection for total protein and creatinine clearance is a more accurate measure of renal function.

Laboratory evaluation of renal function includes electrolytes, blood urea nitrogen (BUN), serum creatinine, serum protein, and uric acid determinations. A normal serum creatinine value during pregnancy is less than 1 mg/dL and a normal creatinine clearance is 115 to 150 mL/minute.52 As serum creatinine increases or creatinine clearance declines, the woman is at increased risk for magnesium toxicity or renal impairment. Creatinine clearance approximates glomerular filtration rate and may be calculated by the following formula:53

CrCl = (140 - age) X weight(kg) X 0.85
72 X serumCr
Placement of an indwelling Foley catheter with urometer facilitates accurate assessment of fluid balance and early signs of renal compromise. The presence of oliguria in the woman laboring with a Foley catheter may indicate fetal descent, causing a mechanical obstruction of the catheter.

Hematologic Assessment. Hematologic assessments are monitored to identify signs of hemolysis, coagulation defects, and decreased oxygen carrying capacity. Monitoring of RBC count can identify anemia or the presence of hemolysis, both of which decrease oxygen-carrying capacity. Morphologic study of RBC will also indicate the presence of hemolysis, in that Burr cells and schistocytes will be present. Determining the status of platelet number and function identifies an evolving coagulopathy. Women are at increased risk of hemorrhage once platelet counts fall below 100,000 X 109/L.54

Central Nervous System Assessment. Assessments of the CNS are performed to identify signs of hypoxemia, increasing CNS irritability, increasing intracranial pressure, cerebral hemorrhage, and magnesium toxicity. For the woman receiving magnesium sulfate, deep tendon reflexes (DTRs) are assessed and the findings recorded. The most frequent DTRs evaluated are knee-jerk response. Deep tendon reflexes should be present, but not hyperactive (1+ to 2+). The evaluation of DTR is especially important if the woman is being treated with magnesium sulfate; absence of DTR is an early indication of impending magnesium toxicity. Assess the woman's level of consciousness and identify changes in behavior or the presence of apprehension, anxiety, or restlessness. Such findings may be early indications of evolving pulmonary edema or hypoxemia. The presence of a headache, visual changes or changes in behavior or level of mentation may be early signs of increasing intracranial pressure.

Fetal Assessments. An important ongoing assessment is determination of fetal status. Uteroplacental perfusion is decreased in women with preeclampsia, thereby placing the fetus in jeopardy. The spiral arteries of the placental bed are subject to vasospasm. When this occurs, perfusion between maternal circulation and the intervillous space is compromised, decreasing blood flow and oxygenation to the fetus. Oligohydramnios, intrauterine growth restriction, fetal stress, and intrauterine fetal death are all associated with preeclampsia. The fetal heart rate is assessed for baseline rate, variability, and reassuring versus nonreassuring patterns. The presence of abnormal baseline rate, decreased or absent variability, or late decelerations are indications of fetal intolerance to its intrauterine environment. The presence of variable decelerations are suggestive of decreased amniotic fluid volumes (oligohydramnios), increasing the risk of umbilical cord compression and fetal compromise. Biophysical or biochemical monitoring for fetal well-being may be ordered: fetal movement counts, nonstress testing, contraction stress testing, biophysical profile, and serial ultrasonographic scanning.2,43

Uterine tonicity is evaluated for signs of labor and abruptio placentae. If labor is suspected, a vaginal examination for cervical changes is indicated. Early signs of abruptio placentae are uterine tenderness and fetal tachycardia; the presence of vaginal bleeding is not necessary for diagnosis.

Laboratory Tests
The nurse assists in obtaining a number of blood and urine specimens to aid in the diagnosis and management of severe preeclampsia, HELLP syndrome, or eclampsia. At present, no known laboratory tests predict the development of preeclampsia or eclampsia. Baseline laboratory test information is useful in the early diagnosis of preeclampsia and for comparison with results obtained to evaluate progression and severity of disease. See Table 5 for common laboratory values assessed in the woman with hypertension during pregnancy.

Pharmacologic Therapies
Pharmacologic therapies are used for seizure prophylaxis and antihypertensive management. (See Table 6 for common pharmacologic therapies for the hypertensive disorders of pregnancy).

Seizure Prophylaxis
Magnesium sulfate. Magnesium sulfate (MgSO4) is the drug of choice in the management of preeclampsia to prevent seizure activity. MgSO4 is always administered as a secondary infusion, through an infusion-controlled device to achieve serum levels of approximately 5 to 8 mg/dL (4 to 7 mEq/dL). The loading dose is a 4-to 6-g bolus administered intravenously in 15 to 30 minutes; followed by a maintenance infusion of 2 to 3 g/hour.2,5,36

The action of magnesium sulfate as an anticonvulsant is controversial, but it is thought to decrease neuromuscular irritability and block the release of acetylcholine at neuromuscular junctions, depressing the vasomotor center, thereby depressing central nervous system irritability.

Side effects of magnesium sulfate are dose dependent and include: flushing, nausea, vomiting, headache, lower maternal temperature, blurred vision, respiratory depression, and cardiac arrest. The effect of magnesium sulfate on fetal heart baseline variability is controversial; a decrease in baseline variability may be seen.

Nursing responsibilities and assessments for the woman receiving magnesium sulfate include assessment of maternal baseline vital signs, deep tendon reflexes, and urinary output before initiation of therapy and reassessment according to institution protocol; preparation of MgSO4 according to protocol; establishment of primary intravenous infusion and administration of MgSO4 as a secondary infusion through an infusion-control device; documentation of MgSO4 infusion in grams per hour; accurate fetal assessment; keeping calcium gluconate at bedside (antidote for magnesium toxicity); exercising caution in concurrent administration of narcotics, CNS depressants, calcium channel blockers, and beta blockers; and discontinuation of MgSO4 and notification of primary care provider if signs of toxicity develop (loss of knee-jerk reflexes, respiratory depression, oliguria, respiratory arrest, cardiac arrest) or if the woman complains of shortness of breath or chest pain. If signs of magnesium toxicity occur, be prepared to give 1 g of calcium gluconate (10 mL of a 10% solution), as a slow intravenous bolus.

Phenytoin. Phenytoin has limited use for eclampsia prophylaxis; however, it is not a first-line therapy in the United States.55 Clinical studies have not demonstrated better results with phenytoin when compared with those obtained with magnesium sulfate. Because of the lack of obstetric experience with phenytoin and significant maternal side effects, magnesium sulfate remains the first-line drug in the United States.

Antihypertensive Therapy
Pharmacologic therapies directed at the control of significant hypertension include a variety of agents. There are several general precautions to be considered when antihypertensive agents are ordered during pregnancy: When blood pressure is sustained at or greater than 160 mmHg systolic or 110 mmHg diastolic, antihypertensive therapy is initiated to prevent maternal cerebral vascular accident; effect of the agent may depend on intravascular volume status and hypovolemia, secondary to increased capillary permeability and hemoconcentration, which may need correction before the initiation of therapy; and diastolic blood pressure should be maintained between 90 to 100 mmHg to sustain uteroplacental perfusion.

Hydralazine hydrochloride. Hydralazine hydrochloride (Apresoline) is considered by many to be the first-line agent to decrease hypertension. Dosage regimens vary, but intermittent intravenous boluses (5 to 10 mg repeated every 15 to 20 minutes) are generally as effective as continuous infusions; there is also less chance of rebound hypotension with intermittent boluses. Side effects of hydralazine include flushing, headache, maternal and fetal tachycardia, palpitations, uteroplacental insufficiency with subsequent fetal tachycardia, and late decelerations. Because hydralazine increases maternal cardiac output and heart rate, hypertension may worsen.

Labetalol. Labetalol has recently been used in place of hydralazine for the management of hypertension. If hydralazine is used as a first-line antihypertensive agent, labetalol is then given as a second-line drug. Dosage regimes vary, based on physician experience and preference. Labetalol is contraindicated in women with asthma and in those with greater than first-degree heart block.56 Rebound hypotension is less common with labetalol than with hydralazine hydrochloride.56 Because of labetalol's alpha and beta adrenergic blockade, transient fetal and neonatal hypotension, bradycardia, and hypoglycemia are possible.

Nifedipine. Nifedipine (Procardia) may be used as a third line agent in the treatment of hypertension. Again, protocols vary. With the administration of nifedipine, a calcium channel blocker, care must be taken with concomitant administration with magnesium sulfate and beta blockers, in that these drugs may potentiate each other.

Other Antihypertensive Agents. For women experiencing a hypertensive crisis or for those in whom traditional therapy fails, alternative antihypertensive agents may be used. Nitroglycerin is used for hypertension refractory to conservative pharmacologic therapy. It works to relax predominantly venous but also arterial vascular smooth muscle and will decrease preload at low doses and afterload at high doses. Side effects include hypotension, tachycardia, nausea, vomiting, pallor, sweating, headache, flushing, and methemoglobinemia (intravenous doses greater than 7 mg/kg per minute). Fetal stress may occur with a mean arterial pressure less than 106 mmHg and fetal heart rate variability may be diminished. Sodium nitroprusside (Nipride) is indicated for severe hypertension or hypertensive crisis. Nipride is a potent vasodilator with direct effect on arterial and venous smooth muscle. Side effects include nausea, diaphoresis, anxiety, headache, bradycardia, changes in electrocardiograph, tachycardia, raised intracranial pressure, decreased reflexes, blurred vision, and cyanide toxicity. Fetal side effects are possible because sodium nitroprusside crosses the placental barrier.

Postpartum Management
After birth, most women will stabilize within 48 hours. However, because of the risk of eclampsia during the first 24 to 48 hours, careful monitoring of vital signs, level of consciousness, and DTRs and laboratory assessments are continued. Additional assessments focus on identifying the development of postpartum hemorrhage, disseminated intra-vascular coagulopathy, pulmonary edema, HELLP syndrome, increased intracranial pressure, and intracranial hemorrhage. Intravenous MgSO4 is continued for at least the first 24 hours after birth. Immediate postpartum curettage has been associated with a more rapid recovery in cases of severe preeclampsia, although more research is needed in this area.57,58 Efforts are made to initiate maternal-newborn attachment by bringing the newborn, if stable, to visit the mother. Photographs of the newborn can be taken and provided to the woman if either maternal or newborn condition prevents visitation.

Summary
The most common medical complication of pregnancy is hypertension. Women diagnosed with the HELLP syndrome or eclampsia present a variety of management issues and problems for the health care provider. Regardless of the diagnosis, severe pre-eclampsia, the HELLP syndrome, or eclampsia can profoundly affect the woman and her fetus. The underlying pathophysiology must be evaluated and treated with both patients in mind at all times. Nurses caring for the woman diagnosed with severe preeclampsia, the HELLP syndrome, and eclampsia must be fully aware of the risk factors, diagnostic criteria, appropriate management regimes, and the potential complications for both the woman and her fetus.

References
1. Poole J. Legal and professional issues in critical care obstetrics. Crit Care Nurs Clin North Am 1992;4:687-690.
2. Sibai B. Hypertension in pregnancy. In Gabbe S, Niebyl J, Simpson J, eds. Obstetrics: Normal & Problem Pregnancies. 3rd ed. New York: Churchill Livingstone; 1996: 935-996.
3. Berg C, Atrash H, Koonin L, Tucker M. Pregnancy-related mortality in the United States, 1987-1990. Obstet Gynecol 1996;88: 161-167.
4. Wilcox L, Marks J. From Data to Action: CDC's Public Health Surveillance for Women, Infants, and Children. Washington, DC,: US Department of Health & Human Services, Public Health Services, Centers for Disease Control and Prevention; 1994:412.
5. American College of Obstetricians and Gynecologists. Management of preeclampsia. ACOG Tech Bull 1996;219.
6. Duley L. Maternal mortality associated with hypertensive disorders of pregnancy in Africa, Asia, Latin America and the Caribbean. Br J Obstet Gynaecol 1992;99:547-553.
7. Ventura S, Martin J, Taffel S, Mathews T, Clarke S. Advance Report of Final Natality Statistics, 1993. Monthly Vital Statistics Report. Hyattsville, MD: National Center for Health Statistics; 1995:1-88.
8. Friedman SA, Taylor RN, Roberts JN. Pathophysiology of preeclampsia. Clin Perinatol 1991;18:661-682.
9. Robertson WB, Khong TY. Pathology of the uteroplacental bed. In Sharp F, Symonds EM, eds. Hypertension in Pregnancy. Ithaca, NY: Perinatology Press; 1987:101.
10. Davies AM, Czaczkes JW, Sadovsky E. Toxemia of pregnancy in Jerusalem. I. Epidemiological studies of a total community. Isr J Med Sci 1970;6:253.
11. Davies AG. Geographical Epidemiology of the Toxemias of Pregnancy. Springfield IL: Charles C Thomas; 1971.
12. Easterling TR, Benedetti TJ. Preeclampsia: A hyperdynamic disease model. Am J Obstet Gynecol 1989;160:1447-1453.
13. Easterling TR. The maternal hemodynamics of preeclampsia. Clin Obstet Gynecol 1992;35: 375-386.
14. Roberts J, Taylor R, Goldfien A. Endothelial cell activation as a pathogenetic factor in preeclampsia. Semin Perinatol 1991;15:86-93.
15. Taylor RN, Casal DC, Jones LA. Selective effects of preeclamptic sera on human endothelial cell procoagulant protein expression. Am J Obstet Gynecol 1991;165:1705-1710.
16. Zeeman GG, Dekker GA. Pathogenesis of preeclampsia: A hypothesis. Clin Obstet Gynecol 1992;35:317-337.
17. Belfort M, Anthony J, Saade G, et al. The oxygen consumption/oxygen delivery curve in severe preeclampsia: Evidence for a fixed oxygen extraction state. Am J Obstet Gynecol 1993;169:1448-1455.
18. Sibai BM. The HELLP syndrome (hemolysis, elevated liver enzymes, and low platelets): Much ado about nothing? Am J Obstet Gynecol 1990;162:311-316.
19. Weinstein L. Syndrome of hemolysis, elevated liver enzymes, and low platelet count: A severe consequence of hypertension in pregnancy. Am J Obstet Gynecol 1982;142: 159-163.
20. Dildy GA, Phelan JP, Cotton DB. Complications of pregnancy-induced hypertension. In Clark SL, Cotton DB, Hankins GDV, Phelan JP, eds. Critical Care Obstetrics. 2nd ed. Boston: Blackwell Scientific Publications; 1991: 251-288.
21. Schobel H, Fischer T, Heuszer K, Geiger H, Schmieder R. Preeclampsia: A state of sympathetic overactivation. N Engl J Med 1996;335: 1480-1485.
22. MacGillivary I, Rose GA, Rowe D. Blood pressure survey in pregnancy. Clin Sci 1969;37: 395-407.
23. Moutquin JM, Fainville RN, Raynauld P. A prospective study of blood pressure in pregnancy: Prediction of preeclampsia. Am J Obstet Gynecol 1985;151:191-196.
24. Villar MA, Sibai BM. Clinical significance of elevated mean arterial blood pressure in second trimester and threshold increase in systolic and diastolic blood pressure during third trimester. Am J Obstet Gynecol 1989;160: 419-423.
25. Mabie WC, Pernoll ML, Biswas MK. Chronic hypertension in pregnancy. Obstet Gynecol 1986;67:197-205.
26. MacGillivary I. Some observations on the incidence of pre-eclampsia. Br J Obstet Gynecol 1958;65:536-543.
27. Meyer N, Mercer B, Friedman S, Sibai B. Urinary dipstick protein: A poor predictor of absent or severe proteinuria. Am J Obstet Gynecol 1994;170:137-141.
28. O'Brien WF. Predicting preeclampsia. Obstet Gynecol 1990;75:445û=-456.
29. O'Brien WF. The prediction of preeclampsia. Clin Obstet Gynecol 1992;35:351-364.
30. Poole JH. Getting perspective on HELLP syndrome. Am J Matern Child Nurs 1988;13: 432-437.
31. Poole JH. HELLP syndrome and coagulopathies of pregnancy. Crit Care Nurs Clin North Am 1993;5:475-487.
32. Simpson K. Acute fatty liver of pregnancy. J Obstet Gynecol Neonat Nurs 1993;22: 213-219.
33. Weinstein L. Preeclampsia/eclampsia with hemolysis, elevated liver enzymes, and thrombocytopenia. Obstet Gynecol 1985;66: 657-661.
34. Martin JN, Blake PG, Perry KG, McCaul J, Hess L, Martin R. The natural history of HELLP syndrome: Patterns of disease progression and regression. Am J Obstet Gynecol 1991; 164:1500-1513.
35. Fairlie FM, Sibai BM. Hypertensive diseases in pregnancy. In Reece EA, Hobbins JC, Mahoney MJ, Petrie RH, eds. Medicine of the Fetus and Mother. Philadelphia: J.B. Lippincott; 1993.
36. Sibai B. Treatment of hypertension in pregnant women. N Engl J Med 1996;335:257-265.
37. Cunningham FG, MacDonald PC, Gant NF, Leveno KJ, Gilstrap LC, III. Williams Obstetrics. 19th ed. Norwalk, CT: Appleton & Lange; 1993.
38. American College of Obstetricians and Gynecologists. Invasive hemodynamic monitoring in obstetrics and gynecology. ACOG Tech Bull 1992;175.
39. Clark SL, Cotton DB, Hankins GDV, Phelan JP. Handbook of Critical Care Obstetrics. Boston: Blackwell Scientific Publications; 1994.
40. Clark SL, Greenspoon JS, Aldahl D, Phelan JP. Severe preeclampsia with persistent oliguria: Management of hemodynamic subsets. Am J Obstet Gynecol 1986;154:490-494.
41. Lee W, Gonik B, Cotton DB . Urinary diagnostic indices in preeclampsia-associated oliguria: Correlation with invasive hemodynamic monitoring. Am J Obstet Gynecol 1987;156: 100-103.
42. Repke JT. Hypertension and preeclampsia. In Moore TR, Reiter RC, Rebar RW, Baker VV, eds. Gynecology & Obstetrics: A Longitudinal Approach. New York: Churchill Livingstone; 1993:463-477.
43. Cunningham F, MacDonald P, Gant N, et al. Williams Obstetrics. 20th ed. Stamford, CT: Appleton & Lange; 1997.
44. Redman CWG, Beilin LJ, Bonner J. Treatment of hypertension in pregnancy with methyldopa: Blood pressure control and side effects. Br J Obstet Gynecol 1977;84:419-422.
45. Reiss RE, Tizzano TP, O'Shaughnessy RW. The blood pressure course in primiparous pregnancy. A prospective study of 383 women. J Reprod Med 1987;32:523-526.
46. Sibai BM. Pitfalls in diagnosis and management of preeclampsia. Am J Obstet Gynecol 1988;159:1-5.
47. Wichman K, Ryden G, Wichman G. The influence of different positions and Korotkoff sounds on blood pressure measurements in pregnancy. Acta Obstet Gynecol Scand 1984; 118(suppl):25-28.
48. Lindheimer M, Katz A. Renal physiology and disease in pregnancy. In Seldin D, Giebisch G, eds. The Kidney: Physiology and Pathophysiology. 2nd ed. New York: Raven Press; 1992:3371-3431.
49. Wallenburg HCS. Hemodynamics in hypertensive pregnancy. In Rubin PC, ed. Hypertension in Pregnancy: Handbook of Hypertension. Amsterdam: Elsevier; 1988:66-101.
50. Cashion K, Schulz K, Sibai BM, Anderson GD. Consistency of Blood Pressure Measurement and Recording during Pregnancy. 5th Congress ISSHP. Nottingham, England; 1986.
51. Marx GF, Schwalbe SS, Cho E, Whitty JE. Automated blood pressure measurements in laboring women: Are they reliable? Am J Obstet Gynecol 1993;168:796-798.
52. Ramsay M, James D, Steer P, Weiner C, Gonik B. Normal Values in Pregnancy. Philadelphia: WB Saunders; 1996.
53. Schoolwerth A, Gehr T. Clinical Assessment of Renal Function. In Ayres S, Grenvik A, Holbrook P, Shoemaker W, eds. Textbook of Critical Care. 3rd ed. Philadelphia: WB Saunders; 1995:1018-1029.
54. Leduc L, Wheeler JM, Kirshon B, Cotton DB. Coagulation profile in severe preeclampsia. Obstet Gynecol 1992;79:14-18.
55. Repke JT, Friedman SA, Kaplan PW. Prophylaxis of eclamptic seizures: Current controversies. Clin Obstet Gynecol 1992;35:365-374.
56. Chez R, Sibai BM. Labetalol for intrapartum hypertension. Contemp Obstet Gynecol 1994;39:37-38.
57. Magann E, Martin J, Isaacs J, Perry K, Martin R, Meydrech E. Immediate postpartum curettage: Accelerated recovery from severe preeclampsia. Obstet Gynecol 1993;81:502-506.
58. Magann E, Martin JJ. Complicated postpartum preeclampsia/eclampsia. Obstet Gynecol Clin North Am 1995;22:337-356.